TY - JOUR
T1 - Pharmaceutical applications of a nanospectroscopic technique
T2 - Surface-enhanced Raman spectroscopy
AU - Yilmaz, Hulya
AU - Yilmaz, Deniz
AU - Taskin, Irem Culha
AU - Culha, Mustafa
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2022/1
Y1 - 2022/1
N2 - Surface-enhanced Raman spectroscopy (SERS) is a very sensitive technique offering unique opportunities for detection and identification of molecules and molecular structures at extremely low concentrations even in complex sample matrixes. Since a nanostructured noble metal surface is required for the enhancement of Raman scattering, the acquired spectral information naturally originates from nanometer size domains making it a nanospectroscopic technique by breaking the diffraction limit of light. In this review, first Raman spectroscopy, its comparison to other related techniques, its modes and instrumentation are briefly introduced. Then, the SERS mechanism, substrates and the parameters influencing a SERS experiment are discussed. Finally, its applications in pharmaceuticals including drug discovery, drug metabolism, multifunctional chemo-photothermal-therapy-delivery-release-imaging, drug stability and drug/metabolite detection in complex biological samples are summarized and elaborated.
AB - Surface-enhanced Raman spectroscopy (SERS) is a very sensitive technique offering unique opportunities for detection and identification of molecules and molecular structures at extremely low concentrations even in complex sample matrixes. Since a nanostructured noble metal surface is required for the enhancement of Raman scattering, the acquired spectral information naturally originates from nanometer size domains making it a nanospectroscopic technique by breaking the diffraction limit of light. In this review, first Raman spectroscopy, its comparison to other related techniques, its modes and instrumentation are briefly introduced. Then, the SERS mechanism, substrates and the parameters influencing a SERS experiment are discussed. Finally, its applications in pharmaceuticals including drug discovery, drug metabolism, multifunctional chemo-photothermal-therapy-delivery-release-imaging, drug stability and drug/metabolite detection in complex biological samples are summarized and elaborated.
KW - Humans
KW - Nanostructures
KW - Pharmaceutical Preparations
KW - Spectrum Analysis, Raman/methods
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U2 - 10.1016/j.addr.2022.114184
DO - 10.1016/j.addr.2022.114184
M3 - Article
C2 - 35306126
AN - SCOPUS:85126579245
SN - 0169-409X
VL - 184
SP - 114184
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 114184
ER -