Abstract
Ocular toxic effects of intravitreally injected ceftriaxone sodium and its rate of clearance after a single dose were studied in rhesus and cynomolgus monkeys. Doses of 2, 2.5, and 3 mg/0.1 mL were injected into the vitreous cavity. Electroretinograms performed 15 minutes, 24 hours, one week, and two weeks after injection were not significantly different from preinjection electroretinograms. Lens opacification occurred in one eye receiving 2.5 mg of ceftriaxone. Histopathologic findings in the retina were normal in all eyes injected intravitreally. Levels of ceftriaxone after a 2-mg intravitreal dose were 609 mg/L at 0 hours, 434 mg/L at 24 hours, and 19 mg/L at 100 hours in the vitreous; and 1 mg/L at 0 hours, 116 mg/L at 24 hours, and 9 mg/L at 100 hours in the aqueous.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-123 |
| Number of pages | 3 |
| Journal | Archives of Ophthalmology |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1985 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Pharmacokinetic Analysis of Intravitreal Ceftriaxone in Monkeys. / Jay, Walter M.; Aziz, Mervat Z.; Rissing, John Peter; Shockley, Robert K.
In: Archives of Ophthalmology, Vol. 103, No. 1, 01.01.1985, p. 121-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetic Analysis of Intravitreal Ceftriaxone in Monkeys
AU - Jay, Walter M.
AU - Aziz, Mervat Z.
AU - Rissing, John Peter
AU - Shockley, Robert K.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Ocular toxic effects of intravitreally injected ceftriaxone sodium and its rate of clearance after a single dose were studied in rhesus and cynomolgus monkeys. Doses of 2, 2.5, and 3 mg/0.1 mL were injected into the vitreous cavity. Electroretinograms performed 15 minutes, 24 hours, one week, and two weeks after injection were not significantly different from preinjection electroretinograms. Lens opacification occurred in one eye receiving 2.5 mg of ceftriaxone. Histopathologic findings in the retina were normal in all eyes injected intravitreally. Levels of ceftriaxone after a 2-mg intravitreal dose were 609 mg/L at 0 hours, 434 mg/L at 24 hours, and 19 mg/L at 100 hours in the vitreous; and 1 mg/L at 0 hours, 116 mg/L at 24 hours, and 9 mg/L at 100 hours in the aqueous.
AB - Ocular toxic effects of intravitreally injected ceftriaxone sodium and its rate of clearance after a single dose were studied in rhesus and cynomolgus monkeys. Doses of 2, 2.5, and 3 mg/0.1 mL were injected into the vitreous cavity. Electroretinograms performed 15 minutes, 24 hours, one week, and two weeks after injection were not significantly different from preinjection electroretinograms. Lens opacification occurred in one eye receiving 2.5 mg of ceftriaxone. Histopathologic findings in the retina were normal in all eyes injected intravitreally. Levels of ceftriaxone after a 2-mg intravitreal dose were 609 mg/L at 0 hours, 434 mg/L at 24 hours, and 19 mg/L at 100 hours in the vitreous; and 1 mg/L at 0 hours, 116 mg/L at 24 hours, and 9 mg/L at 100 hours in the aqueous.
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U2 - 10.1001/archopht.1985.01050010127035
DO - 10.1001/archopht.1985.01050010127035
M3 - Article
VL - 103
SP - 121
EP - 123
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 1
ER -