Pharmacokinetics of a new inotropic catecholamine in dog plasma using solid phase extraction technology

R. Dixon, J. Hsiao, W. Caldwell

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The pharmacokinetics of a new inotropic catecholamine, N-[2-(3,4-dihydroxyphenyl)-ethyl]-1-methyl-3-(3 carbomylphenyl)-propylamine HCl (KM-13), was studied following i.v. injection of 50 and 100 μg/kg doses to dogs. KM-13 was extracted from plasma using Bond-Elut CN columns and quantified by HPLC with electro-chemical detection. The plasma concentration - time profile of KM-13 following an i.v. bolus was best fitted with a bi-exponential equation and the terminal elimination phase had a half life of about 20 min. The analytical method, with a limit of sensitivity of 2 ng/ml, would appear to have general applicability in studying the pharmacokinetics of synthetic catecholamines.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume59
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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