Pharmacokinetics of a new inotropic catecholamine in dog plasma using solid phase extraction technology

R. Dixon, J. Hsiao, Robert William Caldwell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pharmacokinetics of a new inotropic catecholamine, N-[2-(3,4-dihydroxyphenyl)-ethyl]-1-methyl-3-(3 carbomylphenyl)-propylamine HCl (KM-13), was studied following i.v. injection of 50 and 100 μg/kg doses to dogs. KM-13 was extracted from plasma using Bond-Elut CN columns and quantified by HPLC with electro-chemical detection. The plasma concentration - time profile of KM-13 following an i.v. bolus was best fitted with a bi-exponential equation and the terminal elimination phase had a half life of about 20 min. The analytical method, with a limit of sensitivity of 2 ng/ml, would appear to have general applicability in studying the pharmacokinetics of synthetic catecholamines.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume59
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Pharmacokinetics
Solid Phase Extraction
Catecholamines
Dogs
Technology
Plasmas
Propylamines
Chemical detection
Half-Life
High Pressure Liquid Chromatography
Injections
4-(2-((3-(3-benzenecarboxamide)-1-methylpropyl)amino)ethyl)-1,2-benzenediol

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

@article{8ed8853c6c2e4ba6a5dbb60dc4421e7b,
title = "Pharmacokinetics of a new inotropic catecholamine in dog plasma using solid phase extraction technology",
abstract = "The pharmacokinetics of a new inotropic catecholamine, N-[2-(3,4-dihydroxyphenyl)-ethyl]-1-methyl-3-(3 carbomylphenyl)-propylamine HCl (KM-13), was studied following i.v. injection of 50 and 100 μg/kg doses to dogs. KM-13 was extracted from plasma using Bond-Elut CN columns and quantified by HPLC with electro-chemical detection. The plasma concentration - time profile of KM-13 following an i.v. bolus was best fitted with a bi-exponential equation and the terminal elimination phase had a half life of about 20 min. The analytical method, with a limit of sensitivity of 2 ng/ml, would appear to have general applicability in studying the pharmacokinetics of synthetic catecholamines.",
author = "R. Dixon and J. Hsiao and Caldwell, {Robert William}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "59",
pages = "395--398",
journal = "Research Communications in Chemical Pathology and Pharmacology",
issn = "0034-5164",
publisher = "PJD Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Pharmacokinetics of a new inotropic catecholamine in dog plasma using solid phase extraction technology

AU - Dixon, R.

AU - Hsiao, J.

AU - Caldwell, Robert William

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The pharmacokinetics of a new inotropic catecholamine, N-[2-(3,4-dihydroxyphenyl)-ethyl]-1-methyl-3-(3 carbomylphenyl)-propylamine HCl (KM-13), was studied following i.v. injection of 50 and 100 μg/kg doses to dogs. KM-13 was extracted from plasma using Bond-Elut CN columns and quantified by HPLC with electro-chemical detection. The plasma concentration - time profile of KM-13 following an i.v. bolus was best fitted with a bi-exponential equation and the terminal elimination phase had a half life of about 20 min. The analytical method, with a limit of sensitivity of 2 ng/ml, would appear to have general applicability in studying the pharmacokinetics of synthetic catecholamines.

AB - The pharmacokinetics of a new inotropic catecholamine, N-[2-(3,4-dihydroxyphenyl)-ethyl]-1-methyl-3-(3 carbomylphenyl)-propylamine HCl (KM-13), was studied following i.v. injection of 50 and 100 μg/kg doses to dogs. KM-13 was extracted from plasma using Bond-Elut CN columns and quantified by HPLC with electro-chemical detection. The plasma concentration - time profile of KM-13 following an i.v. bolus was best fitted with a bi-exponential equation and the terminal elimination phase had a half life of about 20 min. The analytical method, with a limit of sensitivity of 2 ng/ml, would appear to have general applicability in studying the pharmacokinetics of synthetic catecholamines.

UR - http://www.scopus.com/inward/record.url?scp=0023856222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023856222&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 395

EP - 398

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

SN - 0034-5164

IS - 3

ER -