Abstract
This phase I study evaluated selective JAK2 inhibitor XL019 in 30 patients with myelofibrosis. The initial dose cohorts were 100, 200, and 300. mg orally on days 1-21 of a 28-day cycle. Central and/or peripheral neurotoxicity developed in all patients. Subsequently, patients were treated on lower doses; neurotoxicity was again observed, leading to study termination. Peripheral neuropathy resolved in 50%, and central neurotoxicity in all patients within months after therapy cessation. Myelosuppression was minimal. The terminal half-life of XL019 was approximately 21. h, with steady state reached by Day 8. International Working Group defined responses were seen in three (10%) patients.
Original language | English (US) |
---|---|
Pages (from-to) | 316-322 |
Number of pages | 7 |
Journal | Leukemia Research |
Volume | 38 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2014 |
Externally published | Yes |
Keywords
- Inhibitor
- JAK2
- Mutation
- Myelofibrosis
- XL019
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research