Phase II study of an alternate carboplatin and gemcitabine dosing schedule in advanced non-small-cell lung cancer

Frank E. Mott, Christian T. Cable, Neeraj Sharma

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We conducted a phase II single-institution trial in a homogenous patient population with advanced non-small-cell lung cancer to determine whether changing the carboplatin schedule in the carboplatin/gemcitabine doublet would enhance tolerability and/or results. Thirty patients with stage IIIB (with malignant effusion) or stage IV disease received gemcitabine 1100 mg/m2, days 1 and 8 plus carboplatin at an area under the curve of 5 on day 8. Cycles were repeated every 28 days, up to 6 cycles. A response rate of 10% was demonstrated (none complete), but an additional 45% of patients had stable disease. The median time to progression was 5.8 months and the median survival was 8.3 months. A 1-year survival rate of 27% and a 2-year survival rate of 16% were seen. The main nonhematologic toxicity was non-neutropenic infection. Thrombocytopenia occurred in 8 patients (27%; 7 grade 3, 1 grade 4). Carboplatin/gemcitabine with a day 8 administration of carboplatin is well tolerated with a similar survival to established platinum-based doublets.

Original languageEnglish (US)
Pages (from-to)174-176
Number of pages3
JournalClinical Lung Cancer
Volume5
Issue number3
DOIs
StatePublished - Nov 2003

Keywords

  • Cisplatin
  • Nephrotoxicity
  • Renal toxicity
  • Thrombocytopenia

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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