Abstract
A phase II study of troxacitabine, a non-natural dioxolane nucleoside L-enantiomer, was conducted in patients with chronic myelogenous leukemia in blastic phase (CML-BP). Patients were untreated for BP, or treated with imatinib mesylate (IM) as sole prior therapy for BP. Troxacitabine was given as an intravenous infusion over 30min daily for 5 days at a dose of 8.0mg/m2 per day. Thirty-one patients, 29 (93%) of whom had failed prior IM therapy, received 51 courses of therapy. Grade 3 or 4 toxicities included stomatitis (4%), hand-foot syndrome (18%), and skin rash (12%). Four patients (13%) responded. Troxacitabine-based combinations merit study in IM-resistant CML.
Original language | English (US) |
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Pages (from-to) | 1091-1096 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 27 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2003 |
Externally published | Yes |
Keywords
- Blast phase
- Chronic myelogenous leukemia
- Imatinib mesylate
- Troxacitabine
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research