Abstract
Ten of 23 patients with advanced measurable adenocarcinoma of the pancreas achieved an objective response after treatment with a regimen consisting of streptozotocin, mitomycin‐C and 5‐fluorouracil (SMF). The median duration of response is in excess of 7 months, and responding patients have lived significantly longer than patients with progressive disease (7.5+ months vs. 3 months). The SMF regimen was adequately tolerated. Principal toxicities included myelosuppression, which was generally mild, nausea and vomiting. There was reversible nephrotoxicity in the form of proteinuria in 30% of patients and persistent azotemia in 9% of patients.
Original language | English (US) |
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Pages (from-to) | 387-391 |
Number of pages | 5 |
Journal | Cancer |
Volume | 41 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research