Phenomenology and neurobiology of cocaine withdrawal: Are they related?

Ananda Pathiraja, Donatella Marazziti, Giovanni B. Cassano, Bruce I. Diamond, Richard L. Borison

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

1. 1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluted in a group of 27 cocaine users three days after drug withdrawal. 2. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigated. In a subgroup of 10 patients, both psychopathological and biological measurements were repeated after 5 or 6 weeks. 3. 3. Interpretation of the data by Pearson's analysis showed a statistically significant and positive correlation between Hamilton Rating Scale for Depression (HAM-D) scores and period of use. A trend towards a negative correlation, which however did not reach the statistical significance, was found between 3H-Imipramine binding and period of cocaine use, number of days of abstinence and HAM-D scores 4. 4. When compared with normal volunteers at baseline, patients had significantly lower Bmax and Kd values which returned towards normal values after 5 or 6 weeks of cocaine withdrawal. 5. 5. These results indicate the presence of a decreased platelet imipramine binding during cocaine withdrawal which may be due to the effect of the drug or alternatively, a result of concomitant depression which may be primary or secondary in origin. The decreased imipramine binding is a reversible phenomenon, since it increases with the time, in parallel with the improvement of depressive symptoms.

Original languageEnglish (US)
Pages (from-to)1021-1034
Number of pages14
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume19
Issue number6
DOIs
StatePublished - Jan 1 1995

Fingerprint

Neurobiology
Cocaine
Imipramine
Depression
Blood Platelets
Pharmaceutical Preparations
Healthy Volunteers
Reference Values

Keywords

  • cocaine
  • cocaine craving
  • cocaine withdrawal
  • depression
  • imipramine binding
  • platelets
  • serotonin
  • serotonin uptake

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Phenomenology and neurobiology of cocaine withdrawal : Are they related? / Pathiraja, Ananda; Marazziti, Donatella; Cassano, Giovanni B.; Diamond, Bruce I.; Borison, Richard L.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 19, No. 6, 01.01.1995, p. 1021-1034.

Research output: Contribution to journalArticle

Pathiraja, Ananda ; Marazziti, Donatella ; Cassano, Giovanni B. ; Diamond, Bruce I. ; Borison, Richard L. / Phenomenology and neurobiology of cocaine withdrawal : Are they related?. In: Progress in Neuropsychopharmacology and Biological Psychiatry. 1995 ; Vol. 19, No. 6. pp. 1021-1034.
@article{85f08160c34a46159b58dc067502d7f8,
title = "Phenomenology and neurobiology of cocaine withdrawal: Are they related?",
abstract = "1. 1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluted in a group of 27 cocaine users three days after drug withdrawal. 2. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and {"}post-cocaine depression{"} were also investigated. In a subgroup of 10 patients, both psychopathological and biological measurements were repeated after 5 or 6 weeks. 3. 3. Interpretation of the data by Pearson's analysis showed a statistically significant and positive correlation between Hamilton Rating Scale for Depression (HAM-D) scores and period of use. A trend towards a negative correlation, which however did not reach the statistical significance, was found between 3H-Imipramine binding and period of cocaine use, number of days of abstinence and HAM-D scores 4. 4. When compared with normal volunteers at baseline, patients had significantly lower Bmax and Kd values which returned towards normal values after 5 or 6 weeks of cocaine withdrawal. 5. 5. These results indicate the presence of a decreased platelet imipramine binding during cocaine withdrawal which may be due to the effect of the drug or alternatively, a result of concomitant depression which may be primary or secondary in origin. The decreased imipramine binding is a reversible phenomenon, since it increases with the time, in parallel with the improvement of depressive symptoms.",
keywords = "cocaine, cocaine craving, cocaine withdrawal, depression, imipramine binding, platelets, serotonin, serotonin uptake",
author = "Ananda Pathiraja and Donatella Marazziti and Cassano, {Giovanni B.} and Diamond, {Bruce I.} and Borison, {Richard L.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/0278-5846(95)00194-8",
language = "English (US)",
volume = "19",
pages = "1021--1034",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Phenomenology and neurobiology of cocaine withdrawal

T2 - Are they related?

AU - Pathiraja, Ananda

AU - Marazziti, Donatella

AU - Cassano, Giovanni B.

AU - Diamond, Bruce I.

AU - Borison, Richard L.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - 1. 1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluted in a group of 27 cocaine users three days after drug withdrawal. 2. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigated. In a subgroup of 10 patients, both psychopathological and biological measurements were repeated after 5 or 6 weeks. 3. 3. Interpretation of the data by Pearson's analysis showed a statistically significant and positive correlation between Hamilton Rating Scale for Depression (HAM-D) scores and period of use. A trend towards a negative correlation, which however did not reach the statistical significance, was found between 3H-Imipramine binding and period of cocaine use, number of days of abstinence and HAM-D scores 4. 4. When compared with normal volunteers at baseline, patients had significantly lower Bmax and Kd values which returned towards normal values after 5 or 6 weeks of cocaine withdrawal. 5. 5. These results indicate the presence of a decreased platelet imipramine binding during cocaine withdrawal which may be due to the effect of the drug or alternatively, a result of concomitant depression which may be primary or secondary in origin. The decreased imipramine binding is a reversible phenomenon, since it increases with the time, in parallel with the improvement of depressive symptoms.

AB - 1. 1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluted in a group of 27 cocaine users three days after drug withdrawal. 2. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigated. In a subgroup of 10 patients, both psychopathological and biological measurements were repeated after 5 or 6 weeks. 3. 3. Interpretation of the data by Pearson's analysis showed a statistically significant and positive correlation between Hamilton Rating Scale for Depression (HAM-D) scores and period of use. A trend towards a negative correlation, which however did not reach the statistical significance, was found between 3H-Imipramine binding and period of cocaine use, number of days of abstinence and HAM-D scores 4. 4. When compared with normal volunteers at baseline, patients had significantly lower Bmax and Kd values which returned towards normal values after 5 or 6 weeks of cocaine withdrawal. 5. 5. These results indicate the presence of a decreased platelet imipramine binding during cocaine withdrawal which may be due to the effect of the drug or alternatively, a result of concomitant depression which may be primary or secondary in origin. The decreased imipramine binding is a reversible phenomenon, since it increases with the time, in parallel with the improvement of depressive symptoms.

KW - cocaine

KW - cocaine craving

KW - cocaine withdrawal

KW - depression

KW - imipramine binding

KW - platelets

KW - serotonin

KW - serotonin uptake

UR - http://www.scopus.com/inward/record.url?scp=0028879470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028879470&partnerID=8YFLogxK

U2 - 10.1016/0278-5846(95)00194-8

DO - 10.1016/0278-5846(95)00194-8

M3 - Article

C2 - 8584680

AN - SCOPUS:0028879470

VL - 19

SP - 1021

EP - 1034

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 6

ER -