(Chemical Equation Presented) The prodigiosin alkaloid 1 and the synthetic analogue 2 show photoinduced cytotoxicity against HL-60 cancer cells. Photoirradiation of 1 and 2 causes photofading, photooxidation, and thioadduct formation. These results provide a model for the redox properties of prodigiosins that play a role in their biological activity and provide a new way to functionalize their pyrromethene entity with water-soluble thiol groups.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Oct 12 2006|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry