Physical training improves insulin resistance syndrome markers in obese adolescents

Hyun Sik Kang, Bernard Gutin, Paule Barbeau, Scott Owens, Christian Lemmon, Jerry David Allison, Mark S. Litaker, Ngoc Anh Le

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Introduction: The purpose of this study was to test the hypothesis that physical training (PT), especially high-intensity PT, would have a favorable effect on components of the insulin resistance syndrome (IRS) in obese adolescents. Methods: Obese 13- to 16-yr-olds (N = 80) were randomly assigned to one of the following 8-month interventions; 1) lifestyle education (LSE)-alone every 2 wk, 2) LSE+moderate-intensity PT, and 3) LSE+high-intensity PT. PT was offered 5 d·wk-1. Plasma triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very low-density lipoprotein cholesterol (VLDLC), low-density lipoprotein cholesterol (LDLC), low-density lipoprotein (low density lipoprotein (LDL)) particle size, apolipoproteins AI and B, glucose, insulin, and blood pressure were measured with standardized methods. Results: The intent-to-treat analyses for all subjects who completed preand post-tests regardless of their adherence to the interventions showed that the LSE+high-intensity PT group had more favorable changes than the LSE-alone group in TAG level (P = 0.012), TC/HDLC (P = 0.013), and diastolic blood pressure (P = 0.031). For efficacy analyses, all PT subjects who attended at least 2 d·wk-1 (40%) were combined into one group (LSE+PT) and compared with the LSE-alone group. These two-group analyses showed significant interactions (P < 0.001) between baseline values and group membership for ΔTAG, ΔVLDLC, and ΔTC/HDLC, such that subjects who had the least favorable baseline values showed the most beneficial impact of the PT. Of particular interest was a favorable effect of the PT on LDL particle size. Conclusion: PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.

Original languageEnglish (US)
Pages (from-to)1920-1927
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint

Insulin Resistance
Life Style
Education
LDL Lipoproteins
HDL Cholesterol
VLDL Cholesterol
Triglycerides
Cholesterol
Blood Pressure
Particle Size
Physical Education and Training
Apolipoprotein A-I
Apolipoproteins B
LDL Cholesterol
Glucose

Keywords

  • Body composition
  • Exercise
  • Insulin resistance syndrome
  • LDL particle size
  • Visceral adiposity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Physical training improves insulin resistance syndrome markers in obese adolescents. / Kang, Hyun Sik; Gutin, Bernard; Barbeau, Paule; Owens, Scott; Lemmon, Christian; Allison, Jerry David; Litaker, Mark S.; Le, Ngoc Anh.

In: Medicine and Science in Sports and Exercise, Vol. 34, No. 12, 01.12.2002, p. 1920-1927.

Research output: Contribution to journalArticle

Kang, Hyun Sik ; Gutin, Bernard ; Barbeau, Paule ; Owens, Scott ; Lemmon, Christian ; Allison, Jerry David ; Litaker, Mark S. ; Le, Ngoc Anh. / Physical training improves insulin resistance syndrome markers in obese adolescents. In: Medicine and Science in Sports and Exercise. 2002 ; Vol. 34, No. 12. pp. 1920-1927.
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abstract = "Introduction: The purpose of this study was to test the hypothesis that physical training (PT), especially high-intensity PT, would have a favorable effect on components of the insulin resistance syndrome (IRS) in obese adolescents. Methods: Obese 13- to 16-yr-olds (N = 80) were randomly assigned to one of the following 8-month interventions; 1) lifestyle education (LSE)-alone every 2 wk, 2) LSE+moderate-intensity PT, and 3) LSE+high-intensity PT. PT was offered 5 d·wk-1. Plasma triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very low-density lipoprotein cholesterol (VLDLC), low-density lipoprotein cholesterol (LDLC), low-density lipoprotein (low density lipoprotein (LDL)) particle size, apolipoproteins AI and B, glucose, insulin, and blood pressure were measured with standardized methods. Results: The intent-to-treat analyses for all subjects who completed preand post-tests regardless of their adherence to the interventions showed that the LSE+high-intensity PT group had more favorable changes than the LSE-alone group in TAG level (P = 0.012), TC/HDLC (P = 0.013), and diastolic blood pressure (P = 0.031). For efficacy analyses, all PT subjects who attended at least 2 d·wk-1 (40{\%}) were combined into one group (LSE+PT) and compared with the LSE-alone group. These two-group analyses showed significant interactions (P < 0.001) between baseline values and group membership for ΔTAG, ΔVLDLC, and ΔTC/HDLC, such that subjects who had the least favorable baseline values showed the most beneficial impact of the PT. Of particular interest was a favorable effect of the PT on LDL particle size. Conclusion: PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.",
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AU - Kang, Hyun Sik

AU - Gutin, Bernard

AU - Barbeau, Paule

AU - Owens, Scott

AU - Lemmon, Christian

AU - Allison, Jerry David

AU - Litaker, Mark S.

AU - Le, Ngoc Anh

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AB - Introduction: The purpose of this study was to test the hypothesis that physical training (PT), especially high-intensity PT, would have a favorable effect on components of the insulin resistance syndrome (IRS) in obese adolescents. Methods: Obese 13- to 16-yr-olds (N = 80) were randomly assigned to one of the following 8-month interventions; 1) lifestyle education (LSE)-alone every 2 wk, 2) LSE+moderate-intensity PT, and 3) LSE+high-intensity PT. PT was offered 5 d·wk-1. Plasma triacylglycerol (TAG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very low-density lipoprotein cholesterol (VLDLC), low-density lipoprotein cholesterol (LDLC), low-density lipoprotein (low density lipoprotein (LDL)) particle size, apolipoproteins AI and B, glucose, insulin, and blood pressure were measured with standardized methods. Results: The intent-to-treat analyses for all subjects who completed preand post-tests regardless of their adherence to the interventions showed that the LSE+high-intensity PT group had more favorable changes than the LSE-alone group in TAG level (P = 0.012), TC/HDLC (P = 0.013), and diastolic blood pressure (P = 0.031). For efficacy analyses, all PT subjects who attended at least 2 d·wk-1 (40%) were combined into one group (LSE+PT) and compared with the LSE-alone group. These two-group analyses showed significant interactions (P < 0.001) between baseline values and group membership for ΔTAG, ΔVLDLC, and ΔTC/HDLC, such that subjects who had the least favorable baseline values showed the most beneficial impact of the PT. Of particular interest was a favorable effect of the PT on LDL particle size. Conclusion: PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.

KW - Body composition

KW - Exercise

KW - Insulin resistance syndrome

KW - LDL particle size

KW - Visceral adiposity

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