Physiological regulation of magnocellular neurosecretory cell activity

Integration of intrinsic, local and afferent mechanisms

C. H. Brown, J. S. Bains, M. Ludwig, Javier Eduardo Stern

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

The hypothalamic supraoptic and paraventricular nuclei contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the antidiuretic hormone) into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. Although it has long been known that the activity of MNCs depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the MNCs themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity.

Original languageEnglish (US)
Pages (from-to)678-710
Number of pages33
JournalJournal of Neuroendocrinology
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Vasopressins
Oxytocin
Milk Ejection
Posterior Pituitary Gland
Supraoptic Nucleus
Water-Electrolyte Balance
Body Fluids
Vasoconstriction
Neuroglia
Action Potentials
Parturition
Kidney
Water

Keywords

  • Osmoregulation
  • Oxytocin
  • Paraventricular nucleus
  • Reproduction
  • Supraoptic nucleus
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Physiological regulation of magnocellular neurosecretory cell activity : Integration of intrinsic, local and afferent mechanisms. / Brown, C. H.; Bains, J. S.; Ludwig, M.; Stern, Javier Eduardo.

In: Journal of Neuroendocrinology, Vol. 25, No. 8, 01.08.2013, p. 678-710.

Research output: Contribution to journalReview article

Brown, C. H. ; Bains, J. S. ; Ludwig, M. ; Stern, Javier Eduardo. / Physiological regulation of magnocellular neurosecretory cell activity : Integration of intrinsic, local and afferent mechanisms. In: Journal of Neuroendocrinology. 2013 ; Vol. 25, No. 8. pp. 678-710.
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