Physiology of vascular smooth muscle in relation to hypertension

D. F. Bohr, C. A. Bruner, F. S. Lamb, R Clinton Webb

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A wealth of observations can be found of functional differences between the vascular smooth muscle of normotensive and hypertensive animals. Even the least imaginative investigator can and does find evidence among these findings for his pet theory as to what makes the pressure to up. The theory that we support is that the process is initiated by a deficit of calcium binding sites on the plasma membrane. Because of this the membrane lacks stability and is more permeable to various ions. In the case of vascular smooth muscle the most relevant functional change appears to be the more ready opening of the potential sensitive calcium channel.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalActa Physiologica Scandinavica
Volume133
Issue numberSUPPL. 571
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Vascular Smooth Muscle
Hypertension
Pets
Calcium Channels
Binding Sites
Research Personnel
Cell Membrane
Ions
Calcium
Pressure
Membranes

ASJC Scopus subject areas

  • Physiology

Cite this

Bohr, D. F., Bruner, C. A., Lamb, F. S., & Webb, R. C. (1988). Physiology of vascular smooth muscle in relation to hypertension. Acta Physiologica Scandinavica, 133(SUPPL. 571), 15-24.

Physiology of vascular smooth muscle in relation to hypertension. / Bohr, D. F.; Bruner, C. A.; Lamb, F. S.; Webb, R Clinton.

In: Acta Physiologica Scandinavica, Vol. 133, No. SUPPL. 571, 01.01.1988, p. 15-24.

Research output: Contribution to journalArticle

Bohr, DF, Bruner, CA, Lamb, FS & Webb, RC 1988, 'Physiology of vascular smooth muscle in relation to hypertension', Acta Physiologica Scandinavica, vol. 133, no. SUPPL. 571, pp. 15-24.
Bohr, D. F. ; Bruner, C. A. ; Lamb, F. S. ; Webb, R Clinton. / Physiology of vascular smooth muscle in relation to hypertension. In: Acta Physiologica Scandinavica. 1988 ; Vol. 133, No. SUPPL. 571. pp. 15-24.
@article{71580690af234ed2b9027d8cdf31d05b,
title = "Physiology of vascular smooth muscle in relation to hypertension",
abstract = "A wealth of observations can be found of functional differences between the vascular smooth muscle of normotensive and hypertensive animals. Even the least imaginative investigator can and does find evidence among these findings for his pet theory as to what makes the pressure to up. The theory that we support is that the process is initiated by a deficit of calcium binding sites on the plasma membrane. Because of this the membrane lacks stability and is more permeable to various ions. In the case of vascular smooth muscle the most relevant functional change appears to be the more ready opening of the potential sensitive calcium channel.",
author = "Bohr, {D. F.} and Bruner, {C. A.} and Lamb, {F. S.} and Webb, {R Clinton}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "133",
pages = "15--24",
journal = "Acta Physiologica Scandinavica",
issn = "0370-839X",
publisher = "Wiley-Blackwell",
number = "SUPPL. 571",

}

TY - JOUR

T1 - Physiology of vascular smooth muscle in relation to hypertension

AU - Bohr, D. F.

AU - Bruner, C. A.

AU - Lamb, F. S.

AU - Webb, R Clinton

PY - 1988/1/1

Y1 - 1988/1/1

N2 - A wealth of observations can be found of functional differences between the vascular smooth muscle of normotensive and hypertensive animals. Even the least imaginative investigator can and does find evidence among these findings for his pet theory as to what makes the pressure to up. The theory that we support is that the process is initiated by a deficit of calcium binding sites on the plasma membrane. Because of this the membrane lacks stability and is more permeable to various ions. In the case of vascular smooth muscle the most relevant functional change appears to be the more ready opening of the potential sensitive calcium channel.

AB - A wealth of observations can be found of functional differences between the vascular smooth muscle of normotensive and hypertensive animals. Even the least imaginative investigator can and does find evidence among these findings for his pet theory as to what makes the pressure to up. The theory that we support is that the process is initiated by a deficit of calcium binding sites on the plasma membrane. Because of this the membrane lacks stability and is more permeable to various ions. In the case of vascular smooth muscle the most relevant functional change appears to be the more ready opening of the potential sensitive calcium channel.

UR - http://www.scopus.com/inward/record.url?scp=0024199780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024199780&partnerID=8YFLogxK

M3 - Article

C2 - 3071083

AN - SCOPUS:0024199780

VL - 133

SP - 15

EP - 24

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0370-839X

IS - SUPPL. 571

ER -