Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations

Michel Cayouette, Sylvia B Smith, S. Patricia Becerra, Claude Gravel

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor superfamily produced by retinal pigment epithelial cells in the developing and adult retina. In vitro, it induces neuronal differentiation of retinoblastoma cells and promotes survival of cerebellar granule neurons. The pedf gene is closely linked to an autosomal-dominant locus for retinitis pigmentosa, suggesting that PEDF could be a survival factor for photoreceptors. We have investigated this possibility by injecting PEDF into the eyes of homozygous retinal degeneration (rd) and retinal degeneration slow (rds) mice, two mutants displaying apoptotic photoreceptor loss. This procedure resulted in a transient delay of photoreceptor loss in the rd mouse and a reduction in apoptotic photoreceptor profiles in the rds mouse. We conclude that PEDF can act as a survival-promoting factor for photoreceptors in vivo and could potentially be useful for the treatment of photoreceptor diseases.

Original languageEnglish (US)
Pages (from-to)523-532
Number of pages10
JournalNeurobiology of Disease
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1999

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Retinal Degeneration
Serine Proteinase Inhibitors
Retinitis Pigmentosa
Retinal Pigments
Retinoblastoma
Retina
Cell Survival
Epithelial Cells
Neurons
pigment epithelium-derived factor
Genes

ASJC Scopus subject areas

  • Neurology

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Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. / Cayouette, Michel; Smith, Sylvia B; Becerra, S. Patricia; Gravel, Claude.

In: Neurobiology of Disease, Vol. 6, No. 6, 01.01.1999, p. 523-532.

Research output: Contribution to journalArticle

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