PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte

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Abstract

The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 pdKO/mVps34pdKO) mice and demonstrated an indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes.

Original languageEnglish (US)
Pages (from-to)923-924
Number of pages2
JournalAutophagy
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Keywords

  • Aberrant autophagosome
  • Autophagy
  • Glomerulosclerosis
  • PIK3C3
  • Podocyte vacuolization
  • Proteinuria
  • VPS34

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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