Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons

S. P. Clark, Wendy B Bollag, K. N. Westlund, F. Ma, G. Falls, Ding Xie, Maribeth H Johnson, Carlos M Isales, M. H. Bhattacharyya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A commercial resin-based pine oil (PO) derived from Pinus palustris and Pinus elliottii was the major focus of this investigation. Extracts of pine resins, needles, and bark are folk medicines commonly used to treat skin ailments, including burns. The American Burn Association estimates that 500,000 people with burn injuries receive medical treatment each year; one-half of US burn victims are children, most with scald burns. This systematic study was initiated as follow-up to personal anecdotal evidence acquired over more than 10 years by MH Bhattacharyya regarding PO's efficacy for treating burns. The results demonstrate that PO counteracted dermal inflammation in both a mouse ear model of contact irritant-induced dermal inflammation and a second degree scald burn to the mouse paw. Furthermore, PO significantly counteracted the tactile allodynia and soft tissue injury caused by the scald burn. In mouse dorsal root ganglion neuronal cultures, PO added to the medium blocked adenosine triphosphate-activated, but not capsaicin-activated, pain pathways, demonstrating specificity. These results together support the hypothesis that a pine-oil-based treatment can be developed to provide effective in-home care for second degree burns.

Original languageEnglish (US)
Pages (from-to)252-260
Number of pages9
JournalPhytotherapy Research
Volume28
Issue number2
DOIs
StatePublished - Feb 1 2014

Fingerprint

Spinal Ganglia
Oils
Burns
Hot Temperature
Neurons
Wounds and Injuries
Pinus
Skin
Inflammation
Soft Tissue Injuries
Irritants
Capsaicin
Hyperalgesia
Traditional Medicine
Home Care Services
Needles
Ear
Adenosine Triphosphate
Pain
Therapeutics

Keywords

  • dorsal root ganglion (DRG) neuronal cells
  • edema
  • mouse
  • pain
  • pine oil treatment
  • scald burn

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons. / Clark, S. P.; Bollag, Wendy B; Westlund, K. N.; Ma, F.; Falls, G.; Xie, Ding; Johnson, Maribeth H; Isales, Carlos M; Bhattacharyya, M. H.

In: Phytotherapy Research, Vol. 28, No. 2, 01.02.2014, p. 252-260.

Research output: Contribution to journalArticle

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