Plasma and Developing Enamel Fluoride Concentrations During Chronic Acid-base Disturbances

Gary M. Whitford, Keith E. Reynolds

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Mild acid-base disturbances were induced in rats for 30 days. These disturbances did not affect % ash of maxillary incisors or % P of the developing enamel from mandibular incisors. Total fluoride intake (food and water) among groups drinking fluoride-free water was constant. Nevertheless, average plasma and developing enamel fluoride concentrations were highest in the acidotic group and lowest in the alkalotic group. Among groups drinking water containing 50 ppm fluoride, total fluoride intake was highest by the alkalotic group and lowest by the acidotic group. Plasma and enamel fluoride concentrations, however, were highest in the acidotic group. It is concluded that plasma and developing enamel fluoride levels can be independent of, or inversely related to, fluoride intake.

Original languageEnglish (US)
Pages (from-to)2058-2065
Number of pages8
JournalJournal of Dental Research
Volume58
Issue number11
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Dentistry(all)

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