TY - JOUR
T1 - Plasma interleukin-1β concentration is associated with stroke in sickle cell disease
AU - Asare, Kwaku
AU - Gee, Beatrice E.
AU - Stiles, Jonathan K.
AU - Wilson, Nana O.
AU - Driss, Adel
AU - Quarshie, Alexander
AU - Adams, Robert J.
AU - Kutlar, Abdullah
AU - Hibbert, Jacqueline M.
N1 - Funding Information:
This work was supported by the National Institutes of Health (NIH)/Fogarty International Center (FIC) postdoctoral training grant in Genomics and Hemoglobinopathies, NIH-FIC-5R90HG004151-03 (to J.K.S.), NIH grants S06 GM008248 (to J.M.H.) and RR033062, G12-RR03034 and P20-RR11104 (to Morehouse School of Medicine).
PY - 2010/1
Y1 - 2010/1
N2 - The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participated in the multi-center stroke prevention (STOP) study, to determine if plasma inflammatory protein concentration is associated with the outcome of stroke. Thirty-nine plasma samples from HbSS participants with elevated TCD who had no stroke, HbSS-NS (n = 13) or had stroke, HbSS-S (n = 13), HbSS steady-state controls (n = 7) and controls with normal hemoglobin, HbAA (n = 6), were analyzed simultaneously for 27 circulating inflammatory proteins. Logistic regression and receiver operating characteristics curve analysis of stroke on plasma inflammatory mediator concentration, adjusted for age and gender, demonstrated that interleukin-1β (IL-1β) was protective against stroke development (HbSS-NS = 19, 17-23, HbSS-S = 17, 16-19 pg/mL, median and 25th-75th percentile; odds ratio = 0.59, C.I. = 0.36-0.96) and was a good predictor of stroke (area under curve = 0.852). This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1β concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS.
AB - The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participated in the multi-center stroke prevention (STOP) study, to determine if plasma inflammatory protein concentration is associated with the outcome of stroke. Thirty-nine plasma samples from HbSS participants with elevated TCD who had no stroke, HbSS-NS (n = 13) or had stroke, HbSS-S (n = 13), HbSS steady-state controls (n = 7) and controls with normal hemoglobin, HbAA (n = 6), were analyzed simultaneously for 27 circulating inflammatory proteins. Logistic regression and receiver operating characteristics curve analysis of stroke on plasma inflammatory mediator concentration, adjusted for age and gender, demonstrated that interleukin-1β (IL-1β) was protective against stroke development (HbSS-NS = 19, 17-23, HbSS-S = 17, 16-19 pg/mL, median and 25th-75th percentile; odds ratio = 0.59, C.I. = 0.36-0.96) and was a good predictor of stroke (area under curve = 0.852). This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1β concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS.
KW - Chemokine
KW - Cytokine
KW - Interleukin-1β
KW - Sickle cell
KW - Stroke
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U2 - 10.1016/j.cyto.2009.10.002
DO - 10.1016/j.cyto.2009.10.002
M3 - Article
C2 - 19900820
AN - SCOPUS:71649094086
SN - 1043-4666
VL - 49
SP - 39
EP - 44
JO - Cytokine
JF - Cytokine
IS - 1
ER -