PLasma Membrane Disruption: Repair, Prevention, Adaptation

Paul L. McNeil, Richard A. Steinhardt

Research output: Contribution to journalArticle

311 Citations (Scopus)

Abstract

Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and cytoskeletal and membrane fusion proteins as its catalysts. Endomembrane is delivered to the damaged plasma membrane through exocytosis, a ubiquitous Ca2+-triggered response to disruption. Tissue and cell level architecture prevent disruptions from occurring, either by shielding cells from damaging levels of force, or, when this is not possible, by promoting safe force transmission through the plasma membrane via protein-based cables and linkages. Prevention of disruption also can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed. Disease results from failure of either the preventive or resealing mechanisms.

Original languageEnglish (US)
Pages (from-to)697-731
Number of pages35
JournalAnnual Review of Cell and Developmental Biology
Volume19
DOIs
StatePublished - Dec 11 2003

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Cell Membrane
Membrane Fusion Proteins
Mechanical Stress
Exocytosis
Blood Proteins
Cell Survival
Membrane Proteins

Keywords

  • Calcium
  • Exocytosis
  • Fusion
  • Injury
  • Resealing

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

PLasma Membrane Disruption : Repair, Prevention, Adaptation. / McNeil, Paul L.; Steinhardt, Richard A.

In: Annual Review of Cell and Developmental Biology, Vol. 19, 11.12.2003, p. 697-731.

Research output: Contribution to journalArticle

McNeil, Paul L. ; Steinhardt, Richard A. / PLasma Membrane Disruption : Repair, Prevention, Adaptation. In: Annual Review of Cell and Developmental Biology. 2003 ; Vol. 19. pp. 697-731.
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