Context: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. Objectives:To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods:A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results:Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion:Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
ASJC Scopus subject areas
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis