Plasma netrin-1 is a diagnostic biomarker of human cancers

Ganesan Ramesh, Arthur Berg, Calpurnia Jayakumar

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Context: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. Objectives:To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods:A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results:Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion:Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalBiomarkers
Volume16
Issue number2
DOIs
StatePublished - Mar 1 2011

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Biomarkers
Tumor Biomarkers
Plasmas
Pituitary Neoplasms
Meningioma
Glioblastoma
Liver
Prostate
Neoplasms
Breast
Kidney
Pancreatic Neoplasms
Colonic Neoplasms
Cues
Lung Neoplasms
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
netrin-1
Tissue
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Plasma netrin-1 is a diagnostic biomarker of human cancers. / Ramesh, Ganesan; Berg, Arthur; Jayakumar, Calpurnia.

In: Biomarkers, Vol. 16, No. 2, 01.03.2011, p. 172-180.

Research output: Contribution to journalArticle

Ramesh, G, Berg, A & Jayakumar, C 2011, 'Plasma netrin-1 is a diagnostic biomarker of human cancers', Biomarkers, vol. 16, no. 2, pp. 172-180. https://doi.org/10.3109/1354750X.2010.541564
Ramesh, Ganesan ; Berg, Arthur ; Jayakumar, Calpurnia. / Plasma netrin-1 is a diagnostic biomarker of human cancers. In: Biomarkers. 2011 ; Vol. 16, No. 2. pp. 172-180.
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