Plasma renin activity is associated with bone mineral density in premenopausal women

F. A. Tylavsky, K. C. Johnson, J. Y. Wan, Gregory A Harshfield

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bone mineral density (BMD), plasma renin activity (PRA) and dietary calcium and sodium were evaluated in 47 Caucasian premenopausal women. All subjects were free of any disorder or medications known to affect calcium or bone metabolism. Those subjects with low PRA (< 1.3 ng/ml) had 4.3% lower BMD at the distal radius (p = 0.03). Other skeletal sites appeared to have lower BMD in subjects with low PRA but these differences were not statistically significant. There was a tendency for the low PRA group to have a lower dietary intake of calcium (p = 0.06) as compared with the normal PRA group (≤ 1.3 and < 4.0 ng/ml). Positive correlations were found between calcium intake and PRA (r = 0.26, p = 0.09); and between calcium/sodium intake and distal radial BMD (r = 0.31, p = 0.04), mid-radial BMD (r = 0.30, p = 0.04), total hip BMD (r = 0.23, p = 0.12) and total body BMD (r = 0.27, p = 0.07). This study provides preliminary evidence that a sodium intake > 3400 mg/day, as evidenced by the suppression of PRA, may affect bone mass and the effect may be modified by the level of calcium intake. Additional research is needed to replicate our findings with a larger sample size.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalOsteoporosis International
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Renin
Bone Density
Calcium
Dietary Sodium
Bone and Bones
Dietary Calcium
Sample Size
Research

Keywords

  • Bone density
  • Dietary calcium
  • Dietary sodium
  • Females
  • Renin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma renin activity is associated with bone mineral density in premenopausal women. / Tylavsky, F. A.; Johnson, K. C.; Wan, J. Y.; Harshfield, Gregory A.

In: Osteoporosis International, Vol. 8, No. 2, 01.01.1998, p. 136-140.

Research output: Contribution to journalArticle

Tylavsky, F. A. ; Johnson, K. C. ; Wan, J. Y. ; Harshfield, Gregory A. / Plasma renin activity is associated with bone mineral density in premenopausal women. In: Osteoporosis International. 1998 ; Vol. 8, No. 2. pp. 136-140.
@article{d30cee6f4a8f4c0088d80b35534d44a9,
title = "Plasma renin activity is associated with bone mineral density in premenopausal women",
abstract = "Bone mineral density (BMD), plasma renin activity (PRA) and dietary calcium and sodium were evaluated in 47 Caucasian premenopausal women. All subjects were free of any disorder or medications known to affect calcium or bone metabolism. Those subjects with low PRA (< 1.3 ng/ml) had 4.3{\%} lower BMD at the distal radius (p = 0.03). Other skeletal sites appeared to have lower BMD in subjects with low PRA but these differences were not statistically significant. There was a tendency for the low PRA group to have a lower dietary intake of calcium (p = 0.06) as compared with the normal PRA group (≤ 1.3 and < 4.0 ng/ml). Positive correlations were found between calcium intake and PRA (r = 0.26, p = 0.09); and between calcium/sodium intake and distal radial BMD (r = 0.31, p = 0.04), mid-radial BMD (r = 0.30, p = 0.04), total hip BMD (r = 0.23, p = 0.12) and total body BMD (r = 0.27, p = 0.07). This study provides preliminary evidence that a sodium intake > 3400 mg/day, as evidenced by the suppression of PRA, may affect bone mass and the effect may be modified by the level of calcium intake. Additional research is needed to replicate our findings with a larger sample size.",
keywords = "Bone density, Dietary calcium, Dietary sodium, Females, Renin",
author = "Tylavsky, {F. A.} and Johnson, {K. C.} and Wan, {J. Y.} and Harshfield, {Gregory A}",
year = "1998",
month = "1",
day = "1",
doi = "10.1007/BF02672509",
language = "English (US)",
volume = "8",
pages = "136--140",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "2",

}

TY - JOUR

T1 - Plasma renin activity is associated with bone mineral density in premenopausal women

AU - Tylavsky, F. A.

AU - Johnson, K. C.

AU - Wan, J. Y.

AU - Harshfield, Gregory A

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Bone mineral density (BMD), plasma renin activity (PRA) and dietary calcium and sodium were evaluated in 47 Caucasian premenopausal women. All subjects were free of any disorder or medications known to affect calcium or bone metabolism. Those subjects with low PRA (< 1.3 ng/ml) had 4.3% lower BMD at the distal radius (p = 0.03). Other skeletal sites appeared to have lower BMD in subjects with low PRA but these differences were not statistically significant. There was a tendency for the low PRA group to have a lower dietary intake of calcium (p = 0.06) as compared with the normal PRA group (≤ 1.3 and < 4.0 ng/ml). Positive correlations were found between calcium intake and PRA (r = 0.26, p = 0.09); and between calcium/sodium intake and distal radial BMD (r = 0.31, p = 0.04), mid-radial BMD (r = 0.30, p = 0.04), total hip BMD (r = 0.23, p = 0.12) and total body BMD (r = 0.27, p = 0.07). This study provides preliminary evidence that a sodium intake > 3400 mg/day, as evidenced by the suppression of PRA, may affect bone mass and the effect may be modified by the level of calcium intake. Additional research is needed to replicate our findings with a larger sample size.

AB - Bone mineral density (BMD), plasma renin activity (PRA) and dietary calcium and sodium were evaluated in 47 Caucasian premenopausal women. All subjects were free of any disorder or medications known to affect calcium or bone metabolism. Those subjects with low PRA (< 1.3 ng/ml) had 4.3% lower BMD at the distal radius (p = 0.03). Other skeletal sites appeared to have lower BMD in subjects with low PRA but these differences were not statistically significant. There was a tendency for the low PRA group to have a lower dietary intake of calcium (p = 0.06) as compared with the normal PRA group (≤ 1.3 and < 4.0 ng/ml). Positive correlations were found between calcium intake and PRA (r = 0.26, p = 0.09); and between calcium/sodium intake and distal radial BMD (r = 0.31, p = 0.04), mid-radial BMD (r = 0.30, p = 0.04), total hip BMD (r = 0.23, p = 0.12) and total body BMD (r = 0.27, p = 0.07). This study provides preliminary evidence that a sodium intake > 3400 mg/day, as evidenced by the suppression of PRA, may affect bone mass and the effect may be modified by the level of calcium intake. Additional research is needed to replicate our findings with a larger sample size.

KW - Bone density

KW - Dietary calcium

KW - Dietary sodium

KW - Females

KW - Renin

UR - http://www.scopus.com/inward/record.url?scp=0031971780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031971780&partnerID=8YFLogxK

U2 - 10.1007/BF02672509

DO - 10.1007/BF02672509

M3 - Article

C2 - 9666936

AN - SCOPUS:0031971780

VL - 8

SP - 136

EP - 140

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 2

ER -