TY - JOUR
T1 - Plasma thrombosis markers following cerebral infarction in African Americans
AU - Bruno, Askiel
AU - McConnell, Joseph P.
AU - Cohen, Stanley N.
AU - Tietjen, Gretchen E.
AU - Richardson, De Juran
AU - Gorelick, Philip B.
AU - Bang, Nils U.
N1 - Funding Information:
This study was supported by a grant from Roche Laboratories. Statistical assistance provided by the African American Antiplatelet Stroke Prevention Study Data Management Center, grant R01 NS33430 from the NINDS. We thank Anette S. Odgaard, MT (ASCP), from the Special Coagulation Laboratory at Indiana University Hospital for expert assistance with the assays and Carol Kempf, RN, for subject recruitment, follow-up, and sample collections.
PY - 2005
Y1 - 2005
N2 - Our aim was to evaluate plasma thrombosis markers following non-cardioembolic cerebral infarction for possible correlation with recurrent vascular events. We enrolled 88 subjects treated with antiplatelet drugs and followed them for 2 years with plasma fibrinogen, F1.2, TAT, and D-dimer measurements at baseline, 6, 12, and 24 months. Vascular events were cerebral infarction, myocardial infarction, or vascular death. Recurrent vascular events occurred in 13 subjects and did not correlate with any of the markers, at baseline or during follow-up. There were large within-subject fluctuations in fibrinogen, F1.2, and TAT levels and the D-dimer changed between normal and abnormal in 48% of subjects. This pilot study did not detect a trend for a difference in plasma fibrinogen, F1.2, TAT, or D-dimer levels between African Americans with and without recurrent vascular events following cerebral infarction. Large within-subject fluctuations in these marker levels may limit their usefulness as predictors of vascular events in clinical practice.
AB - Our aim was to evaluate plasma thrombosis markers following non-cardioembolic cerebral infarction for possible correlation with recurrent vascular events. We enrolled 88 subjects treated with antiplatelet drugs and followed them for 2 years with plasma fibrinogen, F1.2, TAT, and D-dimer measurements at baseline, 6, 12, and 24 months. Vascular events were cerebral infarction, myocardial infarction, or vascular death. Recurrent vascular events occurred in 13 subjects and did not correlate with any of the markers, at baseline or during follow-up. There were large within-subject fluctuations in fibrinogen, F1.2, and TAT levels and the D-dimer changed between normal and abnormal in 48% of subjects. This pilot study did not detect a trend for a difference in plasma fibrinogen, F1.2, TAT, or D-dimer levels between African Americans with and without recurrent vascular events following cerebral infarction. Large within-subject fluctuations in these marker levels may limit their usefulness as predictors of vascular events in clinical practice.
KW - Atherosclerosis
KW - Infarction
KW - Plasma thrombosis
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U2 - 10.1016/j.thromres.2004.06.043
DO - 10.1016/j.thromres.2004.06.043
M3 - Article
C2 - 15567456
AN - SCOPUS:9644281623
SN - 0049-3848
VL - 115
SP - 73
EP - 77
JO - Thrombosis Research
JF - Thrombosis Research
IS - 1-2
ER -