Our aim was to evaluate plasma thrombosis markers following non-cardioembolic cerebral infarction for possible correlation with recurrent vascular events. We enrolled 88 subjects treated with antiplatelet drugs and followed them for 2 years with plasma fibrinogen, F1.2, TAT, and D-dimer measurements at baseline, 6, 12, and 24 months. Vascular events were cerebral infarction, myocardial infarction, or vascular death. Recurrent vascular events occurred in 13 subjects and did not correlate with any of the markers, at baseline or during follow-up. There were large within-subject fluctuations in fibrinogen, F1.2, and TAT levels and the D-dimer changed between normal and abnormal in 48% of subjects. This pilot study did not detect a trend for a difference in plasma fibrinogen, F1.2, TAT, or D-dimer levels between African Americans with and without recurrent vascular events following cerebral infarction. Large within-subject fluctuations in these marker levels may limit their usefulness as predictors of vascular events in clinical practice.
- Plasma thrombosis
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