Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Charles S. Bryan; Ellen Parker; Patricia V Schoenlein; Jimmie Northey; Bert Ely; Joseph F. John

doi:10.1016/S0196-6553(80)80026-5

Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Charles S. Bryan, Ellen Parker, Patricia V Schoenlein, Jimmie Northey, Bert Ely, Joseph F. John

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.

Original language	English (US)
Pages (from-to)	65-71
Number of pages	7
Journal	American Journal of Infection Control
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/S0196-6553(80)80026-5
State	Published - Jan 1 1980
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Health Policy
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0196-6553(80)80026-5

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abstract = "A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.",

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