Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Charles S. Bryan, Ellen Parker, Patricia V Schoenlein, Jimmie Northey, Bert Ely, Joseph F. John

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalAmerican Journal of Infection Control
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Microbial Drug Resistance
Gentamicins
Plasmids
Serratia
Serratia marcescens
Amikacin
Disease Outbreaks
Serratia Infections
Veterans Hospitals
Patient Transfer
United States Department of Veterans Affairs
Klebsiella pneumoniae
Medical Schools
Teaching Hospitals
Bacteria
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Plasmid-mediated antibiotic resistance in a changing hospital environment : Efficacy of control measures. / Bryan, Charles S.; Parker, Ellen; Schoenlein, Patricia V; Northey, Jimmie; Ely, Bert; John, Joseph F.

In: American Journal of Infection Control, Vol. 8, No. 3, 01.01.1980, p. 65-71.

Research output: Contribution to journalArticle

Bryan, Charles S. ; Parker, Ellen ; Schoenlein, Patricia V ; Northey, Jimmie ; Ely, Bert ; John, Joseph F. / Plasmid-mediated antibiotic resistance in a changing hospital environment : Efficacy of control measures. In: American Journal of Infection Control. 1980 ; Vol. 8, No. 3. pp. 65-71.
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