Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Charles S. Bryan, Ellen Parker, Patricia V Schoenlein, Jimmie Northey, Bert Ely, Joseph F. John

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalAmerican Journal of Infection Control
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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