Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy

Emma L. Davey, Rhonda Elizabeth Colombo, Charles Fiorentino, Gary Fahle, Richard T. Davey, Kenneth N. Olivier, Joseph A. Kovacs

Research output: Contribution to journalArticle

Abstract

Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.

Original languageEnglish (US)
Pages (from-to)800-802
Number of pages3
JournalJournal of Investigative Medicine
Volume65
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Pneumocystis
Pulmonary diseases
Assays
Adrenal Cortex Hormones
Genes
DNA
Pneumocystis carinii
Asthma
Therapeutics
Sputum
Chronic Obstructive Pulmonary Disease
Real-Time Polymerase Chain Reaction

Keywords

  • Asthma
  • Lung Diseases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Davey, E. L., Colombo, R. E., Fiorentino, C., Fahle, G., Davey, R. T., Olivier, K. N., & Kovacs, J. A. (2017). Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy. Journal of Investigative Medicine, 65(4), 800-802. https://doi.org/10.1136/jim-2016-000381

Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy. / Davey, Emma L.; Colombo, Rhonda Elizabeth; Fiorentino, Charles; Fahle, Gary; Davey, Richard T.; Olivier, Kenneth N.; Kovacs, Joseph A.

In: Journal of Investigative Medicine, Vol. 65, No. 4, 01.04.2017, p. 800-802.

Research output: Contribution to journalArticle

Davey, EL, Colombo, RE, Fiorentino, C, Fahle, G, Davey, RT, Olivier, KN & Kovacs, JA 2017, 'Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy', Journal of Investigative Medicine, vol. 65, no. 4, pp. 800-802. https://doi.org/10.1136/jim-2016-000381
Davey, Emma L. ; Colombo, Rhonda Elizabeth ; Fiorentino, Charles ; Fahle, Gary ; Davey, Richard T. ; Olivier, Kenneth N. ; Kovacs, Joseph A. / Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy. In: Journal of Investigative Medicine. 2017 ; Vol. 65, No. 4. pp. 800-802.
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