Abstract
Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 800-802 |
| Number of pages | 3 |
| Journal | Journal of Investigative Medicine |
| Volume | 65 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2017 |
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Keywords
- Asthma
- Lung Diseases
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy. / Davey, Emma L.; Colombo, Rhonda E.; Fiorentino, Charles; Fahle, Gary; Davey, Richard T.; Olivier, Kenneth N.; Kovacs, Joseph A.
In: Journal of Investigative Medicine, Vol. 65, No. 4, 04.2017, p. 800-802.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy
AU - Davey, Emma L.
AU - Colombo, Rhonda E.
AU - Fiorentino, Charles
AU - Fahle, Gary
AU - Davey, Richard T.
AU - Olivier, Kenneth N.
AU - Kovacs, Joseph A.
PY - 2017/4
Y1 - 2017/4
N2 - Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.
AB - Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.
KW - Asthma
KW - Lung Diseases
UR - http://www.scopus.com/inward/record.url?scp=85016991615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016991615&partnerID=8YFLogxK
U2 - 10.1136/jim-2016-000381
DO - 10.1136/jim-2016-000381
M3 - Article
C2 - 28193704
AN - SCOPUS:85016991615
VL - 65
SP - 800
EP - 802
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
SN - 1081-5589
IS - 4
ER -