Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy

Emma L. Davey; Rhonda E. Colombo; Charles Fiorentino; Gary Fahle; Richard T. Davey; Kenneth N. Olivier; Joseph A. Kovacs

doi:10.1136/jim-2016-000381

Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy

Emma L. Davey, Rhonda E. Colombo, Charles Fiorentino, Gary Fahle, Richard T. Davey, Kenneth N. Olivier, Joseph A. Kovacs

Infectious Disease

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.

Original language	English (US)
Pages (from-to)	800-802
Number of pages	3
Journal	Journal of Investigative Medicine
Volume	65
Issue number	4
DOIs	https://doi.org/10.1136/jim-2016-000381
State	Published - Apr 2017

Keywords

Asthma
Lung Diseases

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1136/jim-2016-000381

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title = "Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy",

abstract = "Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.",

keywords = "Asthma, Lung Diseases",

author = "Davey, {Emma L.} and Colombo, {Rhonda E.} and Charles Fiorentino and Gary Fahle and Davey, {Richard T.} and Olivier, {Kenneth N.} and Kovacs, {Joseph A.}",

note = "Funding Information: This research was supported by the Intramural Research Programs of the NIH Clinical Center, the National Institute of Allergy and Infectious Diseases, and the National Heart, Lung, and Blood Institute, National Institutes of Health.",

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AU - Davey, Richard T.

AU - Olivier, Kenneth N.

AU - Kovacs, Joseph A.

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