Policing pregnancy: Tregs help keep the peace

Andrew L. Mellor, David Munn

Research output: Contribution to journalShort survey

26 Scopus citations

Abstract

Effector T cells must be kept under control to suppress autoimmunity and immunity to innocuous antigens encountered at mucosal surfaces. In mice, T cells with regulatory functions are potent suppressors of T-cell responses and can protect tissues from T-cell-mediated destruction. The aim of this research focus is to summarize recent reports suggesting that regulatory T cells (Tregs) might be key components that protect mammalian fetuses from potentially lethal maternal adaptive immunity. Hence, defective generation or function of Tregs might explain some cases of human pregnancy failure.

Original languageEnglish (US)
Pages (from-to)563-565
Number of pages3
JournalTrends in Immunology
Volume25
Issue number11
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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