Polycystic ovary syndrome: An ancient disorder?

Ricardo Azziz; Daniel A. Dumesic; Mark O. Goodarzi

doi:10.1016/j.fertnstert.2010.09.032

Polycystic ovary syndrome: An ancient disorder?

Ricardo Azziz, Daniel A. Dumesic, Mark O. Goodarzi

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Polycystic ovary syndrome (PCOS) appears to be an ancient disorder, which has persisted in human evolution despite reduced fecundity because of the benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants that are eventually found to be associated with PCOS will be similar across ethnic groups and races.

Original language	English (US)
Pages (from-to)	1544-1548
Number of pages	5
Journal	Fertility and sterility
Volume	95
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2010.09.032
State	Published - Apr 2011
Externally published	Yes

Keywords

PCOS
evolution
susceptibility genes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.fertnstert.2010.09.032

Cite this

@article{ffb5cfe8efba42008e035d234a419a59,

title = "Polycystic ovary syndrome: An ancient disorder?",

abstract = "Polycystic ovary syndrome (PCOS) appears to be an ancient disorder, which has persisted in human evolution despite reduced fecundity because of the benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants that are eventually found to be associated with PCOS will be similar across ethnic groups and races.",

keywords = "PCOS, evolution, susceptibility genes",

author = "Ricardo Azziz and Dumesic, {Daniel A.} and Goodarzi, {Mark O.}",

note = "Funding Information: This study was supported in part by National Institutes of Health grant nos. R01-HD29364 (to RA) and R01-DK79888 (to MOG), the Winnick Clinical Scholars Award (to MOG), and an endowment from the Helping Hand of Los Angeles, Inc . ",

year = "2011",

month = apr,

doi = "10.1016/j.fertnstert.2010.09.032",

language = "English (US)",

volume = "95",

pages = "1544--1548",

journal = "Fertility and sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Polycystic ovary syndrome

T2 - An ancient disorder?

AU - Azziz, Ricardo

AU - Dumesic, Daniel A.

AU - Goodarzi, Mark O.

N1 - Funding Information: This study was supported in part by National Institutes of Health grant nos. R01-HD29364 (to RA) and R01-DK79888 (to MOG), the Winnick Clinical Scholars Award (to MOG), and an endowment from the Helping Hand of Los Angeles, Inc .

PY - 2011/4

Y1 - 2011/4

N2 - Polycystic ovary syndrome (PCOS) appears to be an ancient disorder, which has persisted in human evolution despite reduced fecundity because of the benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants that are eventually found to be associated with PCOS will be similar across ethnic groups and races.

AB - Polycystic ovary syndrome (PCOS) appears to be an ancient disorder, which has persisted in human evolution despite reduced fecundity because of the benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants that are eventually found to be associated with PCOS will be similar across ethnic groups and races.

KW - PCOS

KW - evolution

KW - susceptibility genes

UR - http://www.scopus.com/inward/record.url?scp=79952908789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952908789&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2010.09.032

DO - 10.1016/j.fertnstert.2010.09.032

M3 - Article

C2 - 20979996

AN - SCOPUS:79952908789

SN - 0015-0282

VL - 95

SP - 1544

EP - 1548

JO - Fertility and sterility

JF - Fertility and sterility

IS - 5

ER -

Polycystic ovary syndrome: An ancient disorder?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this