TY - JOUR
T1 - Polycystic ovary syndrome is associated with an increased prevalence of irritable bowel syndrome
AU - Mathur, Ruchi
AU - Ko, Ara
AU - Hwang, Laura J.
AU - Low, Kimberly
AU - Azziz, Ricardo
AU - Pimentel, Mark
PY - 2010/4
Y1 - 2010/4
N2 - Introduction: Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women. Irritable bowel syndrome (IBS) is a chronic intestinal disorder that affects up to 20% of adults, more often women. We evaluate if there is a relationship between these common conditions. Methods: Polycystic ovary syndrome and control subjects were prospectively recruited. A questionnaire was given to determine their gastrointestinal symptoms. Body mass index (BMI) and percent body fat were also calculated. Results: About 65 female subjects completed the study. Among the 36 PCOS patients, 15 subjects (42%) had IBS, compared to 3 subjects (10%) among controls (p < 0.01). Control subjects were leaner (BMI: 27.5 ± 1.1 vs. 31.4 ± 1.2 kg/m2, p < 0.05) than PCOS patients. Among women with PCOS, those with IBS had a higher BMI (32.9 ± 2.0 kg/m2) compared to those with PCOS but no IBS (30.3 ± 1.6 kg/m2) and controls (27.5 ± 1.1 kg/m2; p < 0.05). This difference was true even after correcting for BMI and age (p < 0.01). Conclusions: Women with PCOS have a higher prevalence of IBS compared to healthy controls. When IBS is present with PCOS, a higher BMI and percent body fat is seen compared to PCOS alone.
AB - Introduction: Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women. Irritable bowel syndrome (IBS) is a chronic intestinal disorder that affects up to 20% of adults, more often women. We evaluate if there is a relationship between these common conditions. Methods: Polycystic ovary syndrome and control subjects were prospectively recruited. A questionnaire was given to determine their gastrointestinal symptoms. Body mass index (BMI) and percent body fat were also calculated. Results: About 65 female subjects completed the study. Among the 36 PCOS patients, 15 subjects (42%) had IBS, compared to 3 subjects (10%) among controls (p < 0.01). Control subjects were leaner (BMI: 27.5 ± 1.1 vs. 31.4 ± 1.2 kg/m2, p < 0.05) than PCOS patients. Among women with PCOS, those with IBS had a higher BMI (32.9 ± 2.0 kg/m2) compared to those with PCOS but no IBS (30.3 ± 1.6 kg/m2) and controls (27.5 ± 1.1 kg/m2; p < 0.05). This difference was true even after correcting for BMI and age (p < 0.01). Conclusions: Women with PCOS have a higher prevalence of IBS compared to healthy controls. When IBS is present with PCOS, a higher BMI and percent body fat is seen compared to PCOS alone.
KW - Irritable bowel syndrome
KW - Polycystic ovary syndrome
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U2 - 10.1007/s10620-009-0890-5
DO - 10.1007/s10620-009-0890-5
M3 - Article
C2 - 19697132
AN - SCOPUS:77950366420
SN - 0163-2116
VL - 55
SP - 1085
EP - 1089
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 4
ER -