Polymorphism rs13334190 in zinc finger protein 469 (ZNF469) is not a risk factor for keratoconus in a Saudi cohort

Hatem Kalantan, Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Nasser A. Alsabaani, Masoud Ali Alqahtani, Abdulrahman Almummar, Yuato Liu, Khaled K. Abu-Amero

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: Polymorphism rs13334190 in the zinc finger protein 469 gene has been suggested to predispose toward a "thin" cornea, which then becomes keratoconic or is directly pathogenic. Thus, we genotyped polymorphism rs13334190 in 127 unrelated keratoconus cases and 168 control subjects from Saudi Arabia using Taq-Man® assay. Results: The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. A minor allele frequency of 0.068 was comparable to the aggregate rates ranging from 0.060 to 0.086 observed in other populations. Binary logistic regression analysis was performed to ascertain the effects of age, gender and genotype on the likelihood of having keratoconus. The analysis indicated that increased age was statistically significant (p = 0.000) and that females have a 2.19-fold increased risk (p = 0.018) of developing keratoconus. The genotype frequencies did not differ between the sporadic or familial keratoconus cases. Polymorphism rs13334190 is not an independent risk factor for keratoconus in the Saudi cohort.

Original languageEnglish (US)
Article number652
JournalBMC Research Notes
Volume10
Issue number1
DOIs
StatePublished - Nov 29 2017

Keywords

  • Keratoconus
  • rs13334190
  • Saudi
  • ZNF469

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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