Polymorphonuclear cell factor found in patients with rheumatoid arthritis

S. Wakitani, Daitoku Sakamuro, T. Ochi, H. Owaki, M. Fujimoto, K. Ono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The polymorphonuclear (PMN) cell factor was detected in patients with rheumatoid arthritis. The factor was found to stimulate human synovial cells to produce collagenase. The activity was detected in PMN cells accumulated in the epiphyseal bone marrow adjacent to the affected joints in patients with active and severely erosive rheumatoid arthritis, but not in lesions in non-rheumatoid adults. The activity was also found in PMN cells from the synovial fluid of rheumatoid-arthritic joints, but not in PMN cells from the peripheral blood of rheumatoid arthritis patients.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalBiomedical Research
Volume9
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Collagenases
Rheumatoid Arthritis
Bone
Blood
Fluids
Joints
Synovial Fluid
Blood Cells
Bone Marrow

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Polymorphonuclear cell factor found in patients with rheumatoid arthritis. / Wakitani, S.; Sakamuro, Daitoku; Ochi, T.; Owaki, H.; Fujimoto, M.; Ono, K.

In: Biomedical Research, Vol. 9, No. 5, 01.01.1988, p. 395-399.

Research output: Contribution to journalArticle

Wakitani, S. ; Sakamuro, Daitoku ; Ochi, T. ; Owaki, H. ; Fujimoto, M. ; Ono, K. / Polymorphonuclear cell factor found in patients with rheumatoid arthritis. In: Biomedical Research. 1988 ; Vol. 9, No. 5. pp. 395-399.
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