Poor glycemic control induces hypertension in diabetes mellitus

Michael W Brands, Timothy E. Hopkins

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We conducted this study to test the hypothesis that hypertension is a primary consequence of poor glycemic control per se very early in insulin-dependent diabetes mellitus. Sprague-Dawley rats (n = 15) were instrumented with artery and vein catheters, placed in metabolic cages, and sodium intake was clamped throughout the study. Mean arterial pressure was measured 24 h/d. After a precontrol period, streptozotocin (70 mg/kg IV) was administered, and 15 hours later a continuous intravenous insulin infusion was begun at 4 U/rat per day. The insulin infusion was titrated on an individual rat basis to maintain good glycemic control, and after this 7-day control period, blood glucose, urinary sodium excretion, and mean arterial pressure were not different from precontrol values, averaging 8.8 ± 0.6 mmol/L, 2.8 ± 0.2 mmol/d, and 103 ± 2 mm Hg, respectively, for control days 5 through 7. Subsequently, a 4-day period of poor glycemic control was initiated by reducing the insulin infusion rate. Blood glucose, urinary sodium excretion, and mean arterial pressure began to increase on day 1; for diabetes days 3 and 4, they averaged 23.4 ± 1.0 mmol/L, 3.6 ± 0.1 mmol/d, and 110 ± 2 mm Hg, respectively. All were significantly elevated. When insulin treatment was restored, all variables returned to control levels during the next 4 days. A second 4-day diabetic period yielded similar results. These results indicate that elevated blood pressure is a primary consequence of poor glycemic control in insulin-dependent diabetes, occurring before renal injury has had time to develop, and therefore, may be a factor contributing to the initiation of end-organ injury.

Original languageEnglish (US)
Pages (from-to)735-739
Number of pages5
JournalHypertension
Volume27
Issue number3 II
StatePublished - Mar 1 1996
Externally publishedYes

Fingerprint

Diabetes Mellitus
Insulin
Hypertension
Arterial Pressure
Sodium
Blood Glucose
Wounds and Injuries
Streptozocin
Type 1 Diabetes Mellitus
Intravenous Infusions
Sprague Dawley Rats
Veins
Catheters
Arteries
Blood Pressure
Kidney
Therapeutics

Keywords

  • blood pressure
  • diabetes mellitus, insulin-dependent
  • sodium

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Poor glycemic control induces hypertension in diabetes mellitus. / Brands, Michael W; Hopkins, Timothy E.

In: Hypertension, Vol. 27, No. 3 II, 01.03.1996, p. 735-739.

Research output: Contribution to journalArticle

Brands, MW & Hopkins, TE 1996, 'Poor glycemic control induces hypertension in diabetes mellitus', Hypertension, vol. 27, no. 3 II, pp. 735-739.
Brands, Michael W ; Hopkins, Timothy E. / Poor glycemic control induces hypertension in diabetes mellitus. In: Hypertension. 1996 ; Vol. 27, No. 3 II. pp. 735-739.
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