Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia

Veerasathpurush Allareddy, Sivaraman Prakasam, Veerajalandhar Allareddy, Natalia I. Martinez-Schlurmann, Sankeerth Rampa, Romesh P. Nalliah, Sridhar V.K. Eswaran, Satheesh Elangovan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

OBJECTIVE: The objective of this study is to examine the impact of the presence of gingivitis/periodontitis on the occurrence of infectious complications (including septicemia, bacterial infections, and mycoses) in hospitalized leukemic adults in the United States.

METHODS: A retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004-2010 was performed. All hospitalized leukemic patients aged 18 to 65 years were selected. The association between occurrence of gingivitis/periodontitis and infectious complications was examined by multivariable logistic regression models. A total of 135,692 hospitalizations were due to leukemias during the study period. Among these, gingivitis/periodontitis was present in 0.6%. Septicemia occurred in 27.8% of those who had gingivitis/periodontitis (compared to 19.6% in those without gingivitis/periodontitis), bacterial infections occurred in 19.5% of those who had gingivitis/periodontitis (compared to 10.1% in those without gingivitis/periodontitis), and mycoses occurred in 20.7% of those who had gingivitis/periodontitis (compared to 10.7% in those without gingivitis/periodontitis). Patients who had gingivitis/periodontitis were associated with significantly higher odds for septicemia (OR = 1.58, 95% CI = 1.14-2.19, p = 0.01), bacterial infections (OR = 2.15, 95% CI = 1.51-3.07, p<0.01), mycoses (OR = 2.16, 95% CI = 1.43-3.28, p<0.01), or any infectious complication (OR = 2.15, 95% CI = 1.63-2.84, p<0.01) when compared to their counterparts following adjustment for multiple patient and hospital-level confounding factors.

CONCLUSIONS: Poor oral health (as defined by the presence of gingivitis/periodontitis) is an independent predictor of increased risk of infectious complications in hospitalized leukemic adults in the United States.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalJournal of the Massachusetts Dental Society
Volume64
Issue number3
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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    Allareddy, V., Prakasam, S., Allareddy, V., Martinez-Schlurmann, N. I., Rampa, S., Nalliah, R. P., Eswaran, S. V. K., & Elangovan, S. (2015). Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. Journal of the Massachusetts Dental Society, 64(3), 38-42.