Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia

Veerasathpurush Allareddy, Sivaraman Prakasam, Veerajalandhar Allareddy, Natalia I. Martinez-Schlurmann, Sankeerth Rampa, Romesh P. Nalliah, Sridhar V.K. Eswaran, Satheesh Elangovan

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The objective of this study is to examine the impact of the presence of gingivitis/periodontitis on the occurrence of infectious complications (including septicemia, bacterial infections, and mycoses) in hospitalized leukemic adults in the United States.

METHODS: A retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004-2010 was performed. All hospitalized leukemic patients aged 18 to 65 years were selected. The association between occurrence of gingivitis/periodontitis and infectious complications was examined by multivariable logistic regression models. A total of 135,692 hospitalizations were due to leukemias during the study period. Among these, gingivitis/periodontitis was present in 0.6%. Septicemia occurred in 27.8% of those who had gingivitis/periodontitis (compared to 19.6% in those without gingivitis/periodontitis), bacterial infections occurred in 19.5% of those who had gingivitis/periodontitis (compared to 10.1% in those without gingivitis/periodontitis), and mycoses occurred in 20.7% of those who had gingivitis/periodontitis (compared to 10.7% in those without gingivitis/periodontitis). Patients who had gingivitis/periodontitis were associated with significantly higher odds for septicemia (OR = 1.58, 95% CI = 1.14-2.19, p = 0.01), bacterial infections (OR = 2.15, 95% CI = 1.51-3.07, p<0.01), mycoses (OR = 2.16, 95% CI = 1.43-3.28, p<0.01), or any infectious complication (OR = 2.15, 95% CI = 1.63-2.84, p<0.01) when compared to their counterparts following adjustment for multiple patient and hospital-level confounding factors.

CONCLUSIONS: Poor oral health (as defined by the presence of gingivitis/periodontitis) is an independent predictor of increased risk of infectious complications in hospitalized leukemic adults in the United States.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalJournal of the Massachusetts Dental Society
Volume64
Issue number3
StatePublished - Sep 1 2015

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Gingivitis
Periodontitis
Oral Health
Leukemia
Sepsis
Mycoses
Bacterial Infections and Mycoses
Bacterial Infections
Logistic Models
Inpatients
Hospitalization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Allareddy, V., Prakasam, S., Allareddy, V., Martinez-Schlurmann, N. I., Rampa, S., Nalliah, R. P., ... Elangovan, S. (2015). Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. Journal of the Massachusetts Dental Society, 64(3), 38-42.

Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. / Allareddy, Veerasathpurush; Prakasam, Sivaraman; Allareddy, Veerajalandhar; Martinez-Schlurmann, Natalia I.; Rampa, Sankeerth; Nalliah, Romesh P.; Eswaran, Sridhar V.K.; Elangovan, Satheesh.

In: Journal of the Massachusetts Dental Society, Vol. 64, No. 3, 01.09.2015, p. 38-42.

Research output: Contribution to journalArticle

Allareddy, V, Prakasam, S, Allareddy, V, Martinez-Schlurmann, NI, Rampa, S, Nalliah, RP, Eswaran, SVK & Elangovan, S 2015, 'Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia', Journal of the Massachusetts Dental Society, vol. 64, no. 3, pp. 38-42.
Allareddy V, Prakasam S, Allareddy V, Martinez-Schlurmann NI, Rampa S, Nalliah RP et al. Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. Journal of the Massachusetts Dental Society. 2015 Sep 1;64(3):38-42.
Allareddy, Veerasathpurush ; Prakasam, Sivaraman ; Allareddy, Veerajalandhar ; Martinez-Schlurmann, Natalia I. ; Rampa, Sankeerth ; Nalliah, Romesh P. ; Eswaran, Sridhar V.K. ; Elangovan, Satheesh. / Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. In: Journal of the Massachusetts Dental Society. 2015 ; Vol. 64, No. 3. pp. 38-42.
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abstract = "OBJECTIVE: The objective of this study is to examine the impact of the presence of gingivitis/periodontitis on the occurrence of infectious complications (including septicemia, bacterial infections, and mycoses) in hospitalized leukemic adults in the United States.METHODS: A retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004-2010 was performed. All hospitalized leukemic patients aged 18 to 65 years were selected. The association between occurrence of gingivitis/periodontitis and infectious complications was examined by multivariable logistic regression models. A total of 135,692 hospitalizations were due to leukemias during the study period. Among these, gingivitis/periodontitis was present in 0.6{\%}. Septicemia occurred in 27.8{\%} of those who had gingivitis/periodontitis (compared to 19.6{\%} in those without gingivitis/periodontitis), bacterial infections occurred in 19.5{\%} of those who had gingivitis/periodontitis (compared to 10.1{\%} in those without gingivitis/periodontitis), and mycoses occurred in 20.7{\%} of those who had gingivitis/periodontitis (compared to 10.7{\%} in those without gingivitis/periodontitis). Patients who had gingivitis/periodontitis were associated with significantly higher odds for septicemia (OR = 1.58, 95{\%} CI = 1.14-2.19, p = 0.01), bacterial infections (OR = 2.15, 95{\%} CI = 1.51-3.07, p<0.01), mycoses (OR = 2.16, 95{\%} CI = 1.43-3.28, p<0.01), or any infectious complication (OR = 2.15, 95{\%} CI = 1.63-2.84, p<0.01) when compared to their counterparts following adjustment for multiple patient and hospital-level confounding factors.CONCLUSIONS: Poor oral health (as defined by the presence of gingivitis/periodontitis) is an independent predictor of increased risk of infectious complications in hospitalized leukemic adults in the United States.",
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AU - Prakasam, Sivaraman

AU - Allareddy, Veerajalandhar

AU - Martinez-Schlurmann, Natalia I.

AU - Rampa, Sankeerth

AU - Nalliah, Romesh P.

AU - Eswaran, Sridhar V.K.

AU - Elangovan, Satheesh

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N2 - OBJECTIVE: The objective of this study is to examine the impact of the presence of gingivitis/periodontitis on the occurrence of infectious complications (including septicemia, bacterial infections, and mycoses) in hospitalized leukemic adults in the United States.METHODS: A retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004-2010 was performed. All hospitalized leukemic patients aged 18 to 65 years were selected. The association between occurrence of gingivitis/periodontitis and infectious complications was examined by multivariable logistic regression models. A total of 135,692 hospitalizations were due to leukemias during the study period. Among these, gingivitis/periodontitis was present in 0.6%. Septicemia occurred in 27.8% of those who had gingivitis/periodontitis (compared to 19.6% in those without gingivitis/periodontitis), bacterial infections occurred in 19.5% of those who had gingivitis/periodontitis (compared to 10.1% in those without gingivitis/periodontitis), and mycoses occurred in 20.7% of those who had gingivitis/periodontitis (compared to 10.7% in those without gingivitis/periodontitis). Patients who had gingivitis/periodontitis were associated with significantly higher odds for septicemia (OR = 1.58, 95% CI = 1.14-2.19, p = 0.01), bacterial infections (OR = 2.15, 95% CI = 1.51-3.07, p<0.01), mycoses (OR = 2.16, 95% CI = 1.43-3.28, p<0.01), or any infectious complication (OR = 2.15, 95% CI = 1.63-2.84, p<0.01) when compared to their counterparts following adjustment for multiple patient and hospital-level confounding factors.CONCLUSIONS: Poor oral health (as defined by the presence of gingivitis/periodontitis) is an independent predictor of increased risk of infectious complications in hospitalized leukemic adults in the United States.

AB - OBJECTIVE: The objective of this study is to examine the impact of the presence of gingivitis/periodontitis on the occurrence of infectious complications (including septicemia, bacterial infections, and mycoses) in hospitalized leukemic adults in the United States.METHODS: A retrospective analysis of the Nationwide Inpatient Sample (NIS) for the years 2004-2010 was performed. All hospitalized leukemic patients aged 18 to 65 years were selected. The association between occurrence of gingivitis/periodontitis and infectious complications was examined by multivariable logistic regression models. A total of 135,692 hospitalizations were due to leukemias during the study period. Among these, gingivitis/periodontitis was present in 0.6%. Septicemia occurred in 27.8% of those who had gingivitis/periodontitis (compared to 19.6% in those without gingivitis/periodontitis), bacterial infections occurred in 19.5% of those who had gingivitis/periodontitis (compared to 10.1% in those without gingivitis/periodontitis), and mycoses occurred in 20.7% of those who had gingivitis/periodontitis (compared to 10.7% in those without gingivitis/periodontitis). Patients who had gingivitis/periodontitis were associated with significantly higher odds for septicemia (OR = 1.58, 95% CI = 1.14-2.19, p = 0.01), bacterial infections (OR = 2.15, 95% CI = 1.51-3.07, p<0.01), mycoses (OR = 2.16, 95% CI = 1.43-3.28, p<0.01), or any infectious complication (OR = 2.15, 95% CI = 1.63-2.84, p<0.01) when compared to their counterparts following adjustment for multiple patient and hospital-level confounding factors.CONCLUSIONS: Poor oral health (as defined by the presence of gingivitis/periodontitis) is an independent predictor of increased risk of infectious complications in hospitalized leukemic adults in the United States.

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