TY - JOUR
T1 - Poorly treated or unrecognized GERD reduces quality of life in patients with COPD
AU - Rascon-Aguilar, Ivan E.
AU - Pamer, Mark
AU - Wludyka, Peter
AU - Cury, James
AU - Vega, Kenneth J.
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Background: The effect of gastroesophageal reflux disease (GERD) on health-related quality of life (HRQL) in COPD has never been assessed. Aim: To evaluate HRQL in patients with COPD alone compared with those with both COPD and continuing GERD symptoms. Methods: A questionnaire-based, cross-sectional survey was performed. Subjects were recruited from the outpatient pulmonary clinics at the University of Florida Health Science Center/Jacksonville. Included patients had an established diagnosis of COPD. Exclusion criteria were respiratory disorders other than COPD, known esophageal disease, active peptic ulcer disease, Zollinger-Ellison syndrome, mastocytosis, scleroderma, and current alcohol abuse. Those meeting the criteria and agreeing to participate were asked to complete the Mayo Clinic GERQ and SF-36 questionnaires, by either personal or telephone interview. Clinically significant reflux was defined as heartburn and/or acid regurgitation weekly. Study patients were divided into two groups for HRQL analysis based on the GERQ response: COPD+/GERD+ and COPD only. Statistical analysis was performed using the Mann-Whitney-Wilcoxon T test for unequal variables and linear regression was performed using ANOVA. All data are expressed as mean and standard deviation. Results: Eighty-six patients completed both questionnaires. Males were 55% and COPD+/GERD+ patients comprised 37% of the study group. Compared with COPD only, HRQL was reduced across all measures for the COPD+ GERD+ patients and achieved significance for bodily pain (P < 0.02), mental health (P < 0.05), and physical component score (P < 0.05). Conclusion: Patients with COPD and continuing GERD symptoms have reduced HRQL in comparison with those with COPD alone.
AB - Background: The effect of gastroesophageal reflux disease (GERD) on health-related quality of life (HRQL) in COPD has never been assessed. Aim: To evaluate HRQL in patients with COPD alone compared with those with both COPD and continuing GERD symptoms. Methods: A questionnaire-based, cross-sectional survey was performed. Subjects were recruited from the outpatient pulmonary clinics at the University of Florida Health Science Center/Jacksonville. Included patients had an established diagnosis of COPD. Exclusion criteria were respiratory disorders other than COPD, known esophageal disease, active peptic ulcer disease, Zollinger-Ellison syndrome, mastocytosis, scleroderma, and current alcohol abuse. Those meeting the criteria and agreeing to participate were asked to complete the Mayo Clinic GERQ and SF-36 questionnaires, by either personal or telephone interview. Clinically significant reflux was defined as heartburn and/or acid regurgitation weekly. Study patients were divided into two groups for HRQL analysis based on the GERQ response: COPD+/GERD+ and COPD only. Statistical analysis was performed using the Mann-Whitney-Wilcoxon T test for unequal variables and linear regression was performed using ANOVA. All data are expressed as mean and standard deviation. Results: Eighty-six patients completed both questionnaires. Males were 55% and COPD+/GERD+ patients comprised 37% of the study group. Compared with COPD only, HRQL was reduced across all measures for the COPD+ GERD+ patients and achieved significance for bodily pain (P < 0.02), mental health (P < 0.05), and physical component score (P < 0.05). Conclusion: Patients with COPD and continuing GERD symptoms have reduced HRQL in comparison with those with COPD alone.
KW - COPD
KW - GERD
KW - Quality of life
KW - Questionnaire
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U2 - 10.1007/s10620-010-1542-5
DO - 10.1007/s10620-010-1542-5
M3 - Article
C2 - 21221789
AN - SCOPUS:79959730666
SN - 0163-2116
VL - 56
SP - 1976
EP - 1980
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 7
ER -