Population-based estimates of the prevalence of family history of cancer among women

Ingrid J. Hall, Wylie Burke, Steven Scott Coughlin, Nancy C. Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Family history of cancer is recognized as one of the most important risk factors in predicting personal cancer risk. Nevertheless, there are few published population-based estimates of family history prevalence by age categories. Methods: We used responses of female controls (n = 4,754) from the population-based Cancer and Steroid Hormone study (1980-1982) to estimate the frequency of family history of various cancers among female relatives. We determined the age- and race-specific prevalence of family history of breast, ovarian, endometrial, and other cancers in first-degree female relatives of women aged 20-54 years. To evaluate changes in reporting family history over time, we also analyzed responses of control women (n = 1,544) from the Women's Interview Study on Health (WISH) (1990-1992) to estimate the prevalence of family history of breast cancer. Results: The prevalence of a first-degree family history of breast, ovarian, endometrial, and cervical cancers was 6.4% (95% CI 5.7-7.1%), 1.1% (0.8-1.4%), 3.5% (3.0-4.0%), and 2.1% (1.7-2.5%), respectively. Among first-degree female relatives, the prevalence of family history of colon, lung, and thyroid cancers was 2.4% (2.1-2.9%), 1.5% (1.2-1.8%), and 0.5% (0.3-0.7%), respectively. The prevalence of family history of breast and colon cancers increased significantly with respondent's age. Similar results for family history of breast cancer were obtained from an analysis of responses from the WISH. Conclusions: In addition to providing a point of reference for research and health policy, these results may be of interest to providers who care for female patients because of the usefulness of information about family history of cancer for assessing lifetime risk of cancer.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalCommunity Genetics
Volume4
Issue number3
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

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Population
Neoplasms
Breast Neoplasms
Endometrial Neoplasms
Colonic Neoplasms
Interviews
Health
Health Policy
Thyroid Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Lung Neoplasms
Patient Care
Breast
Steroids
Hormones
Research

Keywords

  • Cancer risk
  • Family history
  • Prevalence

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Population-based estimates of the prevalence of family history of cancer among women. / Hall, Ingrid J.; Burke, Wylie; Coughlin, Steven Scott; Lee, Nancy C.

In: Community Genetics, Vol. 4, No. 3, 01.12.2001, p. 134-142.

Research output: Contribution to journalArticle

Hall, Ingrid J. ; Burke, Wylie ; Coughlin, Steven Scott ; Lee, Nancy C. / Population-based estimates of the prevalence of family history of cancer among women. In: Community Genetics. 2001 ; Vol. 4, No. 3. pp. 134-142.
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AB - Objective: Family history of cancer is recognized as one of the most important risk factors in predicting personal cancer risk. Nevertheless, there are few published population-based estimates of family history prevalence by age categories. Methods: We used responses of female controls (n = 4,754) from the population-based Cancer and Steroid Hormone study (1980-1982) to estimate the frequency of family history of various cancers among female relatives. We determined the age- and race-specific prevalence of family history of breast, ovarian, endometrial, and other cancers in first-degree female relatives of women aged 20-54 years. To evaluate changes in reporting family history over time, we also analyzed responses of control women (n = 1,544) from the Women's Interview Study on Health (WISH) (1990-1992) to estimate the prevalence of family history of breast cancer. Results: The prevalence of a first-degree family history of breast, ovarian, endometrial, and cervical cancers was 6.4% (95% CI 5.7-7.1%), 1.1% (0.8-1.4%), 3.5% (3.0-4.0%), and 2.1% (1.7-2.5%), respectively. Among first-degree female relatives, the prevalence of family history of colon, lung, and thyroid cancers was 2.4% (2.1-2.9%), 1.5% (1.2-1.8%), and 0.5% (0.3-0.7%), respectively. The prevalence of family history of breast and colon cancers increased significantly with respondent's age. Similar results for family history of breast cancer were obtained from an analysis of responses from the WISH. Conclusions: In addition to providing a point of reference for research and health policy, these results may be of interest to providers who care for female patients because of the usefulness of information about family history of cancer for assessing lifetime risk of cancer.

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