Population-based outcomes of men with a single negative prostate biopsy: Importance of continued follow-up among older patients

Rashid K. Sayyid, Shabbir M.H. Alibhai, Rinku Sutradhar, Maria Eberg, Kinwah Fung, Zachary W A Klaassen, Hanan Goldberg, Nathan Perlis, Rabii Hussein Madi, Martha Kennedy Terris, David R. Urbach, Neil E. Fleshner

Research output: Contribution to journalArticle

Abstract

Purpose: To determine in Ontario-based men with a single negative transrectal ultrasound-guided prostate biopsy the long-term rates of prostate cancer-specific mortality, diagnosis, and treatment; number of repeat biopsies; and predictors of prostate cancer diagnosis and mortality. Materials and methods: This was a population-based cohort study, using data from linked, validated health administrative databases, of all Ontario-based men with a negative first biopsy between January 1994 and October 2014. Patients were followed from time of first biopsy till death, administrative censoring, or end of study period. Cumulative incidence functions were used to calculate the study outcomes’ cumulative incidences. Univariable and multivariable regression analyses using Fine and Gray's semiparametric proportional hazards model were used to assess predictors of prostate cancer diagnosis and mortality. Results: The study cohort included 95,675 men with a median age of 63.0years. Median follow-up was 8.1years. The 20-year cumulative rates of prostate cancer-specific mortality and diagnosis were 1.8% and 23.7%, respectively. Men ages 70 to 79 and 80 to 84 at initial biopsy had 20-year prostate cancer-specific mortality cumulative rates of 3.2% and 6.4% respectively. The 20-year cumulative rate of receiving radical prostatectomy was 7.6%. Higher socioeconomic status and urban residence were associated with higher diagnosis risks yet lower prostate cancer-specific mortality risks. Conclusions: This is the first population-based study assessing long-term cancer outcomes in North American men with a single negative transrectal ultrasound-guided prostate biopsy. Following a negative initial biopsy, 23.7% of men are still diagnosed with and 1.8% die of prostate cancer within 20years. Cancer-specific mortality outcomes are significantly worse in older men, with prostate cancer mortality rates several times higher than the rest of the population.

Original languageEnglish (US)
Pages (from-to)298.e19-298.e27
JournalUrologic Oncology: Seminars and Original Investigations
Volume37
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Prostate
Prostatic Neoplasms
Biopsy
Mortality
Population
Ontario
Cohort Studies
Incidence
Prostatectomy
Proportional Hazards Models
Social Class
Neoplasms
Regression Analysis
Outcome Assessment (Health Care)
Databases
Health

Keywords

  • Administrative database
  • Diagnosis
  • Health services research
  • Mortality
  • Prostate cancer
  • Sensitivity and specificity

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Population-based outcomes of men with a single negative prostate biopsy : Importance of continued follow-up among older patients. / Sayyid, Rashid K.; Alibhai, Shabbir M.H.; Sutradhar, Rinku; Eberg, Maria; Fung, Kinwah; Klaassen, Zachary W A; Goldberg, Hanan; Perlis, Nathan; Madi, Rabii Hussein; Terris, Martha Kennedy; Urbach, David R.; Fleshner, Neil E.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 37, No. 5, 01.05.2019, p. 298.e19-298.e27.

Research output: Contribution to journalArticle

Sayyid, Rashid K. ; Alibhai, Shabbir M.H. ; Sutradhar, Rinku ; Eberg, Maria ; Fung, Kinwah ; Klaassen, Zachary W A ; Goldberg, Hanan ; Perlis, Nathan ; Madi, Rabii Hussein ; Terris, Martha Kennedy ; Urbach, David R. ; Fleshner, Neil E. / Population-based outcomes of men with a single negative prostate biopsy : Importance of continued follow-up among older patients. In: Urologic Oncology: Seminars and Original Investigations. 2019 ; Vol. 37, No. 5. pp. 298.e19-298.e27.
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abstract = "Purpose: To determine in Ontario-based men with a single negative transrectal ultrasound-guided prostate biopsy the long-term rates of prostate cancer-specific mortality, diagnosis, and treatment; number of repeat biopsies; and predictors of prostate cancer diagnosis and mortality. Materials and methods: This was a population-based cohort study, using data from linked, validated health administrative databases, of all Ontario-based men with a negative first biopsy between January 1994 and October 2014. Patients were followed from time of first biopsy till death, administrative censoring, or end of study period. Cumulative incidence functions were used to calculate the study outcomes’ cumulative incidences. Univariable and multivariable regression analyses using Fine and Gray's semiparametric proportional hazards model were used to assess predictors of prostate cancer diagnosis and mortality. Results: The study cohort included 95,675 men with a median age of 63.0years. Median follow-up was 8.1years. The 20-year cumulative rates of prostate cancer-specific mortality and diagnosis were 1.8{\%} and 23.7{\%}, respectively. Men ages 70 to 79 and 80 to 84 at initial biopsy had 20-year prostate cancer-specific mortality cumulative rates of 3.2{\%} and 6.4{\%} respectively. The 20-year cumulative rate of receiving radical prostatectomy was 7.6{\%}. Higher socioeconomic status and urban residence were associated with higher diagnosis risks yet lower prostate cancer-specific mortality risks. Conclusions: This is the first population-based study assessing long-term cancer outcomes in North American men with a single negative transrectal ultrasound-guided prostate biopsy. Following a negative initial biopsy, 23.7{\%} of men are still diagnosed with and 1.8{\%} die of prostate cancer within 20years. Cancer-specific mortality outcomes are significantly worse in older men, with prostate cancer mortality rates several times higher than the rest of the population.",
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AU - Sayyid, Rashid K.

AU - Alibhai, Shabbir M.H.

AU - Sutradhar, Rinku

AU - Eberg, Maria

AU - Fung, Kinwah

AU - Klaassen, Zachary W A

AU - Goldberg, Hanan

AU - Perlis, Nathan

AU - Madi, Rabii Hussein

AU - Terris, Martha Kennedy

AU - Urbach, David R.

AU - Fleshner, Neil E.

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N2 - Purpose: To determine in Ontario-based men with a single negative transrectal ultrasound-guided prostate biopsy the long-term rates of prostate cancer-specific mortality, diagnosis, and treatment; number of repeat biopsies; and predictors of prostate cancer diagnosis and mortality. Materials and methods: This was a population-based cohort study, using data from linked, validated health administrative databases, of all Ontario-based men with a negative first biopsy between January 1994 and October 2014. Patients were followed from time of first biopsy till death, administrative censoring, or end of study period. Cumulative incidence functions were used to calculate the study outcomes’ cumulative incidences. Univariable and multivariable regression analyses using Fine and Gray's semiparametric proportional hazards model were used to assess predictors of prostate cancer diagnosis and mortality. Results: The study cohort included 95,675 men with a median age of 63.0years. Median follow-up was 8.1years. The 20-year cumulative rates of prostate cancer-specific mortality and diagnosis were 1.8% and 23.7%, respectively. Men ages 70 to 79 and 80 to 84 at initial biopsy had 20-year prostate cancer-specific mortality cumulative rates of 3.2% and 6.4% respectively. The 20-year cumulative rate of receiving radical prostatectomy was 7.6%. Higher socioeconomic status and urban residence were associated with higher diagnosis risks yet lower prostate cancer-specific mortality risks. Conclusions: This is the first population-based study assessing long-term cancer outcomes in North American men with a single negative transrectal ultrasound-guided prostate biopsy. Following a negative initial biopsy, 23.7% of men are still diagnosed with and 1.8% die of prostate cancer within 20years. Cancer-specific mortality outcomes are significantly worse in older men, with prostate cancer mortality rates several times higher than the rest of the population.

AB - Purpose: To determine in Ontario-based men with a single negative transrectal ultrasound-guided prostate biopsy the long-term rates of prostate cancer-specific mortality, diagnosis, and treatment; number of repeat biopsies; and predictors of prostate cancer diagnosis and mortality. Materials and methods: This was a population-based cohort study, using data from linked, validated health administrative databases, of all Ontario-based men with a negative first biopsy between January 1994 and October 2014. Patients were followed from time of first biopsy till death, administrative censoring, or end of study period. Cumulative incidence functions were used to calculate the study outcomes’ cumulative incidences. Univariable and multivariable regression analyses using Fine and Gray's semiparametric proportional hazards model were used to assess predictors of prostate cancer diagnosis and mortality. Results: The study cohort included 95,675 men with a median age of 63.0years. Median follow-up was 8.1years. The 20-year cumulative rates of prostate cancer-specific mortality and diagnosis were 1.8% and 23.7%, respectively. Men ages 70 to 79 and 80 to 84 at initial biopsy had 20-year prostate cancer-specific mortality cumulative rates of 3.2% and 6.4% respectively. The 20-year cumulative rate of receiving radical prostatectomy was 7.6%. Higher socioeconomic status and urban residence were associated with higher diagnosis risks yet lower prostate cancer-specific mortality risks. Conclusions: This is the first population-based study assessing long-term cancer outcomes in North American men with a single negative transrectal ultrasound-guided prostate biopsy. Following a negative initial biopsy, 23.7% of men are still diagnosed with and 1.8% die of prostate cancer within 20years. Cancer-specific mortality outcomes are significantly worse in older men, with prostate cancer mortality rates several times higher than the rest of the population.

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KW - Prostate cancer

KW - Sensitivity and specificity

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