Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity

Pariket M. Dubal, Aykut A Unsal, Sei Y. Chung, Akshay V. Patel, Richard Chan Woo Park, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm of secretory glands of the upper aerodigestive tract. It accounts for 3–5% of head and neck malignancies and most commonly arises from the minor salivary glands of the oral cavity. The clinical behavior of ACC from specific anatomic subsites, including the oral cavity, is not well described in the literature. We aim to elucidate patient demographics, clinicopathologic features, incidence, and survival trends for oral cavity ACC (OCACC). Methods Retrospective population-based analysis of OCACC in the SEER database between 1973 and 2012. Results 1066 OCACC patients were identified, of which 57.7% were female (P < 0.0001). Incidence was 0.049 per 100,000. Whites were most commonly affected (81.1%). The hard palate was the most commonly involved subsite (44.1%). Nodal involvement was seen in 8.4% of cases and distant metastasis was present in 6.2% of cases at the time of presentation. Disease-specific survival (DSS) rates at 1, 5, 10, 15, and 20 years were 97.4%, 83.9%, 69.9%, 57.6%, and 46.2%, respectively. Females had a higher 5-year DSS (87.8%) than males (78.4%, P = 0.0004). Cases treated with surgery had a favorable prognosis regardless of whether they received radiotherapy (P < 0.0001). Nodal involvement reduced 5-year DSS by 51.6% (P < 0.0001), while distant metastasis reduced 5-year DSS by 46.4% (P < 0.0001). Conclusions OCACC is a rare malignancy with females and whites being more commonly affected. At presentation, regional and distant metastases are uncommon. Poor prognostic indicators include male gender, nonsurgical therapy, nodal involvement, and distant metastasis.

Original languageEnglish (US)
Pages (from-to)398-406
Number of pages9
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume37
Issue number5
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

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Adenoid Cystic Carcinoma
Mouth
Population
Neoplasm Metastasis
Survival
Minor Salivary Glands
Hard Palate
Incidence
Neoplasms
Neck
Radiotherapy
Survival Rate
Head
Demography
Databases
Carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity. / Dubal, Pariket M.; Unsal, Aykut A; Chung, Sei Y.; Patel, Akshay V.; Park, Richard Chan Woo; Baredes, Soly; Eloy, Jean Anderson.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 37, No. 5, 01.09.2016, p. 398-406.

Research output: Contribution to journalArticle

Dubal, Pariket M. ; Unsal, Aykut A ; Chung, Sei Y. ; Patel, Akshay V. ; Park, Richard Chan Woo ; Baredes, Soly ; Eloy, Jean Anderson. / Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2016 ; Vol. 37, No. 5. pp. 398-406.
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abstract = "Purpose Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm of secretory glands of the upper aerodigestive tract. It accounts for 3–5{\%} of head and neck malignancies and most commonly arises from the minor salivary glands of the oral cavity. The clinical behavior of ACC from specific anatomic subsites, including the oral cavity, is not well described in the literature. We aim to elucidate patient demographics, clinicopathologic features, incidence, and survival trends for oral cavity ACC (OCACC). Methods Retrospective population-based analysis of OCACC in the SEER database between 1973 and 2012. Results 1066 OCACC patients were identified, of which 57.7{\%} were female (P < 0.0001). Incidence was 0.049 per 100,000. Whites were most commonly affected (81.1{\%}). The hard palate was the most commonly involved subsite (44.1{\%}). Nodal involvement was seen in 8.4{\%} of cases and distant metastasis was present in 6.2{\%} of cases at the time of presentation. Disease-specific survival (DSS) rates at 1, 5, 10, 15, and 20 years were 97.4{\%}, 83.9{\%}, 69.9{\%}, 57.6{\%}, and 46.2{\%}, respectively. Females had a higher 5-year DSS (87.8{\%}) than males (78.4{\%}, P = 0.0004). Cases treated with surgery had a favorable prognosis regardless of whether they received radiotherapy (P < 0.0001). Nodal involvement reduced 5-year DSS by 51.6{\%} (P < 0.0001), while distant metastasis reduced 5-year DSS by 46.4{\%} (P < 0.0001). Conclusions OCACC is a rare malignancy with females and whites being more commonly affected. At presentation, regional and distant metastases are uncommon. Poor prognostic indicators include male gender, nonsurgical therapy, nodal involvement, and distant metastasis.",
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T1 - Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity

AU - Dubal, Pariket M.

AU - Unsal, Aykut A

AU - Chung, Sei Y.

AU - Patel, Akshay V.

AU - Park, Richard Chan Woo

AU - Baredes, Soly

AU - Eloy, Jean Anderson

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm of secretory glands of the upper aerodigestive tract. It accounts for 3–5% of head and neck malignancies and most commonly arises from the minor salivary glands of the oral cavity. The clinical behavior of ACC from specific anatomic subsites, including the oral cavity, is not well described in the literature. We aim to elucidate patient demographics, clinicopathologic features, incidence, and survival trends for oral cavity ACC (OCACC). Methods Retrospective population-based analysis of OCACC in the SEER database between 1973 and 2012. Results 1066 OCACC patients were identified, of which 57.7% were female (P < 0.0001). Incidence was 0.049 per 100,000. Whites were most commonly affected (81.1%). The hard palate was the most commonly involved subsite (44.1%). Nodal involvement was seen in 8.4% of cases and distant metastasis was present in 6.2% of cases at the time of presentation. Disease-specific survival (DSS) rates at 1, 5, 10, 15, and 20 years were 97.4%, 83.9%, 69.9%, 57.6%, and 46.2%, respectively. Females had a higher 5-year DSS (87.8%) than males (78.4%, P = 0.0004). Cases treated with surgery had a favorable prognosis regardless of whether they received radiotherapy (P < 0.0001). Nodal involvement reduced 5-year DSS by 51.6% (P < 0.0001), while distant metastasis reduced 5-year DSS by 46.4% (P < 0.0001). Conclusions OCACC is a rare malignancy with females and whites being more commonly affected. At presentation, regional and distant metastases are uncommon. Poor prognostic indicators include male gender, nonsurgical therapy, nodal involvement, and distant metastasis.

AB - Purpose Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm of secretory glands of the upper aerodigestive tract. It accounts for 3–5% of head and neck malignancies and most commonly arises from the minor salivary glands of the oral cavity. The clinical behavior of ACC from specific anatomic subsites, including the oral cavity, is not well described in the literature. We aim to elucidate patient demographics, clinicopathologic features, incidence, and survival trends for oral cavity ACC (OCACC). Methods Retrospective population-based analysis of OCACC in the SEER database between 1973 and 2012. Results 1066 OCACC patients were identified, of which 57.7% were female (P < 0.0001). Incidence was 0.049 per 100,000. Whites were most commonly affected (81.1%). The hard palate was the most commonly involved subsite (44.1%). Nodal involvement was seen in 8.4% of cases and distant metastasis was present in 6.2% of cases at the time of presentation. Disease-specific survival (DSS) rates at 1, 5, 10, 15, and 20 years were 97.4%, 83.9%, 69.9%, 57.6%, and 46.2%, respectively. Females had a higher 5-year DSS (87.8%) than males (78.4%, P = 0.0004). Cases treated with surgery had a favorable prognosis regardless of whether they received radiotherapy (P < 0.0001). Nodal involvement reduced 5-year DSS by 51.6% (P < 0.0001), while distant metastasis reduced 5-year DSS by 46.4% (P < 0.0001). Conclusions OCACC is a rare malignancy with females and whites being more commonly affected. At presentation, regional and distant metastases are uncommon. Poor prognostic indicators include male gender, nonsurgical therapy, nodal involvement, and distant metastasis.

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