Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications

Shuyi Li, Lynsa Nguyen, Hairong Xiong, Meiyao Wang, Tom C.C. Hu, Jin-Xiong She, Steven M. Serkiz, George G. Wicks, William S. Dynan

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Porous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the porous walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoporous walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications. From the Clinical Editor: Porous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Controlled release
  • Drug delivery
  • Mesoporous
  • Microsphere
  • Silica
  • Single-chain antibody
  • Single-chain antibody variable fragment
  • Small interfering RNA

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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