Abstract
Objective: The objective of the study was to evaluate the current state of clinical assays for total and free testosterone. Participants: The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. Evidence: Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants. Consensus Process: The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations. Conclusions: Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and free testosterone should be established for both genders and children, taking into account the many variables that influence serum testosterone concentration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405-413 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 92 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2007 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Position statement : Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement. / Rosner, William; Auchus, Richard J.; Azziz, Ricardo; Sluss, Patrick M.; Raff, Hershel.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 2, 02.2007, p. 405-413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Position statement
T2 - Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement
AU - Rosner, William
AU - Auchus, Richard J.
AU - Azziz, Ricardo
AU - Sluss, Patrick M.
AU - Raff, Hershel
PY - 2007/2
Y1 - 2007/2
N2 - Objective: The objective of the study was to evaluate the current state of clinical assays for total and free testosterone. Participants: The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. Evidence: Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants. Consensus Process: The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations. Conclusions: Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and free testosterone should be established for both genders and children, taking into account the many variables that influence serum testosterone concentration.
AB - Objective: The objective of the study was to evaluate the current state of clinical assays for total and free testosterone. Participants: The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. Evidence: Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants. Consensus Process: The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations. Conclusions: Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and free testosterone should be established for both genders and children, taking into account the many variables that influence serum testosterone concentration.
UR - http://www.scopus.com/inward/record.url?scp=33846991956&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846991956&partnerID=8YFLogxK
U2 - 10.1210/jc.2006-1864
DO - 10.1210/jc.2006-1864
M3 - Article
C2 - 17090633
AN - SCOPUS:33846991956
VL - 92
SP - 405
EP - 413
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -