Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

Jin Qian, David J Fulton

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Nitric oxide (NO) is a short-lived gaseous signaling molecule. In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of proteins with reactive thiols (S-nitrosylation). The regulation of eNOS activity and NO bioavailability is critical to maintain blood vessel function. The activity of eNOS and ability to generate NO is regulated at the transcriptional, posttranscriptional, and posttranslational levels. Post-translational modifications acutely impact eNOS activity and dysregulation of these mechanisms compromise eNOS activity and foster the development of cardiovascular diseases (CVDs). This review will intergrate past and current literature on the post-translational modifications of eNOS in both health and disease.

Original languageEnglish (US)
Article numberArticle 347
JournalFrontiers in Physiology
Volume4 DEC
DOIs
StatePublished - Dec 1 2013

Fingerprint

Nitric Oxide Synthase Type III
Vascular Endothelium
Blood Vessels
Nitric Oxide
Post Translational Protein Processing
Protein S
Cyclic GMP
Sulfhydryl Compounds
Biological Availability
Cardiovascular Diseases
Health

Keywords

  • ENOS
  • Nitric oxide
  • Post-translational
  • Vascular diseases
  • Vessel

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium. / Qian, Jin; Fulton, David J.

In: Frontiers in Physiology, Vol. 4 DEC, Article 347, 01.12.2013.

Research output: Contribution to journalReview article

@article{bc6a0f39225c4fc1abd8eccfb261f417,
title = "Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium",
abstract = "Nitric oxide (NO) is a short-lived gaseous signaling molecule. In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of proteins with reactive thiols (S-nitrosylation). The regulation of eNOS activity and NO bioavailability is critical to maintain blood vessel function. The activity of eNOS and ability to generate NO is regulated at the transcriptional, posttranscriptional, and posttranslational levels. Post-translational modifications acutely impact eNOS activity and dysregulation of these mechanisms compromise eNOS activity and foster the development of cardiovascular diseases (CVDs). This review will intergrate past and current literature on the post-translational modifications of eNOS in both health and disease.",
keywords = "ENOS, Nitric oxide, Post-translational, Vascular diseases, Vessel",
author = "Jin Qian and Fulton, {David J}",
year = "2013",
month = "12",
day = "1",
doi = "10.3389/fphys.2013.00347",
language = "English (US)",
volume = "4 DEC",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

AU - Qian, Jin

AU - Fulton, David J

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Nitric oxide (NO) is a short-lived gaseous signaling molecule. In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of proteins with reactive thiols (S-nitrosylation). The regulation of eNOS activity and NO bioavailability is critical to maintain blood vessel function. The activity of eNOS and ability to generate NO is regulated at the transcriptional, posttranscriptional, and posttranslational levels. Post-translational modifications acutely impact eNOS activity and dysregulation of these mechanisms compromise eNOS activity and foster the development of cardiovascular diseases (CVDs). This review will intergrate past and current literature on the post-translational modifications of eNOS in both health and disease.

AB - Nitric oxide (NO) is a short-lived gaseous signaling molecule. In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of proteins with reactive thiols (S-nitrosylation). The regulation of eNOS activity and NO bioavailability is critical to maintain blood vessel function. The activity of eNOS and ability to generate NO is regulated at the transcriptional, posttranscriptional, and posttranslational levels. Post-translational modifications acutely impact eNOS activity and dysregulation of these mechanisms compromise eNOS activity and foster the development of cardiovascular diseases (CVDs). This review will intergrate past and current literature on the post-translational modifications of eNOS in both health and disease.

KW - ENOS

KW - Nitric oxide

KW - Post-translational

KW - Vascular diseases

KW - Vessel

UR - http://www.scopus.com/inward/record.url?scp=84891712616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891712616&partnerID=8YFLogxK

U2 - 10.3389/fphys.2013.00347

DO - 10.3389/fphys.2013.00347

M3 - Review article

VL - 4 DEC

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - Article 347

ER -