TY - JOUR
T1 - Posterior Parietal Cortex Encodes Autonomously Selected Motor Plans
AU - Cui, He
AU - Andersen, Richard A.
N1 - Funding Information:
We thank R. Battacharyya, C. Buneo, J. Cho, E. Hwang, and S. Musallam for help during data collection; D. Baldauf, G. Mulliken, and H. Scherberger for helpful discussions during the course of this study; M. Campos, I. Kagan, and D. Rizzuto for valuable comments on the manuscript; K. Pejsa, N. Sammons, and L. Martel for help with animal handling and training; J. Baer and C. Lindsell for veterinary assistance; V. Shcherbatyuk for computer support; and T. Yao for administrative support. This work was supported by National Eye Institute (NEI) and the James G. Boswell Foundation.
PY - 2007/11/8
Y1 - 2007/11/8
N2 - The posterior parietal cortex (PPC) of rhesus monkeys has been found to encode the behavioral meaning of categories of sensory stimuli. When animals are instructed with sensory cues to make either eye or hand movements to a target, PPC cells also show specificity depending on which effector (eye or hand) is instructed for the movement. To determine whether this selectivity retrospectively reflects the behavioral meaning of the cue or prospectively encodes the movement plan, we trained monkeys to autonomously choose to acquire a target in the absence of direct instructions specifying which effector to use. Activity in PPC showed strong specificity for effector choice, with cells in the lateral intraparietal area selective for saccades and cells in the parietal reach region selective for reaches. Such differential activity associated with effector choice under identical stimulus conditions provides definitive evidence that the PPC is prospectively involved in action selection and movement preparation.
AB - The posterior parietal cortex (PPC) of rhesus monkeys has been found to encode the behavioral meaning of categories of sensory stimuli. When animals are instructed with sensory cues to make either eye or hand movements to a target, PPC cells also show specificity depending on which effector (eye or hand) is instructed for the movement. To determine whether this selectivity retrospectively reflects the behavioral meaning of the cue or prospectively encodes the movement plan, we trained monkeys to autonomously choose to acquire a target in the absence of direct instructions specifying which effector to use. Activity in PPC showed strong specificity for effector choice, with cells in the lateral intraparietal area selective for saccades and cells in the parietal reach region selective for reaches. Such differential activity associated with effector choice under identical stimulus conditions provides definitive evidence that the PPC is prospectively involved in action selection and movement preparation.
KW - SYSNEURO
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U2 - 10.1016/j.neuron.2007.09.031
DO - 10.1016/j.neuron.2007.09.031
M3 - Article
C2 - 17988637
AN - SCOPUS:35648930943
SN - 0896-6273
VL - 56
SP - 552
EP - 559
JO - Neuron
JF - Neuron
IS - 3
ER -