Posterior quadrant epilepsy surgery: Predictors of outcome

Kristin L. Davis, Anthony M Murro, Yong D Park, Gregory P Lee, Morris J. Cohen, Joseph R. Smith

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To identify predictors of seizure recurrence following posterior quadrant epilepsy surgery. Methods: Between 1983 and 2008, 43 medically refractory epilepsy patients underwent posterior quadrant epilepsy surgery. Epilepsy surgery involved the occipital lobe in all cases; some cases also included resection of the adjacent parietal or temporal cortex. Using a logistic regression model, we evaluated the relationship between outcome (Engel class I-IV) and 5 outcome predictors: absence of a visual aura, a temporal lobe type aura, versive head movement unaccompanied by a visual aura, non-focal interictal scalp EEG, and surgical pathology other than low grade tumor or cortical dysplasia. We also determined the relative risk for significant post-operative cognitive decline of Wechsler intelligence test score among those receiving complete lobectomies compared to those receiving partial lobectomies. Results: Overall, outcome was favorable at 1 year following surgery: 22 (51.2%) patients Engel class I, 10 (24%) patients Engel class II, 5 (12%) patients Engel class III, and 6 (14%) patients Engel class IV. The 3 best univariate predictors of seizure recurrence were versive head movement unaccompanied by visual aura, non-focal interictal scalp EEG, and pathology other than low grade tumor or cortical dysplasia. A multivariate predictor combining temporal lobe type aura, versive head movement unaccompanied by visual aura, non-focal interictal scalp EEG, and pathology other than low grade tumor or cortical dysplasia was optimum. Complete lobectomy significantly increased the risk of post-operative decline of Wechsler intelligence score. Conclusions: These findings indicate that posterior quadrant epilepsy surgery may provide sustained seizure control. A multivariate model combining temporal lobe type aura, versive head movement unaccompanied by a visual aura, non-focal interictal scalp EEG, and pathology other than low grade tumor or cortical dysplasia may contribute to predicting seizure recurrence following posterior quadrant epilepsy surgery. The extent of cortical resection may predict significant cognitive decline in post-operative Wechsler intelligence score.

Original languageEnglish (US)
Pages (from-to)722-728
Number of pages7
JournalSeizure
Volume21
Issue number9
DOIs
StatePublished - Nov 1 2012

Fingerprint

Epilepsy
Malformations of Cortical Development
Head Movements
Temporal Lobe
Scalp
Electroencephalography
Seizures
Pathology
Intelligence
Recurrence
Neoplasms
Logistic Models
Occipital Lobe
Surgical Pathology
Parietal Lobe
Intelligence Tests

Keywords

  • Epilepsy surgery outcome
  • Neuropsychological assessment
  • Posterior cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Posterior quadrant epilepsy surgery : Predictors of outcome. / Davis, Kristin L.; Murro, Anthony M; Park, Yong D; Lee, Gregory P; Cohen, Morris J.; Smith, Joseph R.

In: Seizure, Vol. 21, No. 9, 01.11.2012, p. 722-728.

Research output: Contribution to journalArticle

Davis, Kristin L. ; Murro, Anthony M ; Park, Yong D ; Lee, Gregory P ; Cohen, Morris J. ; Smith, Joseph R. / Posterior quadrant epilepsy surgery : Predictors of outcome. In: Seizure. 2012 ; Vol. 21, No. 9. pp. 722-728.
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