Posterior segment ophthalmic complications of aplastic anemia.

Monica Agarwal, Steven Yeh, Lisa J. Faia, Rachel J. Bishop, Michael M. Lai, Jeremy Mark Pantin, Phillip Scheinberg, Emily Y. Chew, Eric D. Weichel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Three patients with aplastic anemia were evaluated by the ophthalmology service within 2 months of the aplastic anemia diagnosis for bilateral visual loss. The mean age of diagnosis of aplastic anemia was 14.3 years (range: 5 to 19 years) and the mean follow-up was 25 months (range: 15 to 44 months). All 6 eyes demonstrated choroidal ischemia and vitreous hemorrhage. Pars plana vitrectomy was performed in four eyes of two patients for non-clearing vitreous hemorrhage; one patient was observed. Successful anatomic outcomes were achieved in 3 of 4 eyes that underwent vitrectomy. Initial visual acuity ranged from 20/80 to bare light perception and final visual acuity ranged from 20/20 to no light perception. All patients received immunosuppressive therapy including cyclosporine and anti-thymocyte globulin, and two underwent hematopoietic stem cell transplantation. All patients received perioperative platelet and blood transfusions. Pars plana vitrectomy resulted in functional and anatomic success in the majority of eyes in this series. Coordination of medical and surgical care with the hematology service is advisable to stabilize hematologic parameters prior to undertaking a vitreoretinal procedure.

Original languageEnglish (US)
JournalOphthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
Volume41 Online
StatePublished - Jan 1 2010

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Aplastic Anemia
Vitrectomy
Vitreous Hemorrhage
Temazepam
Visual Acuity
Choroid Hemorrhage
Light
Platelet Transfusion
Antilymphocyte Serum
Hematopoietic Stem Cell Transplantation
Hematology
Ophthalmology
Immunosuppressive Agents
Cyclosporine
Ischemia

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Agarwal, M., Yeh, S., Faia, L. J., Bishop, R. J., Lai, M. M., Pantin, J. M., ... Weichel, E. D. (2010). Posterior segment ophthalmic complications of aplastic anemia. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye, 41 Online.

Posterior segment ophthalmic complications of aplastic anemia. / Agarwal, Monica; Yeh, Steven; Faia, Lisa J.; Bishop, Rachel J.; Lai, Michael M.; Pantin, Jeremy Mark; Scheinberg, Phillip; Chew, Emily Y.; Weichel, Eric D.

In: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye, Vol. 41 Online, 01.01.2010.

Research output: Contribution to journalArticle

Agarwal, M, Yeh, S, Faia, LJ, Bishop, RJ, Lai, MM, Pantin, JM, Scheinberg, P, Chew, EY & Weichel, ED 2010, 'Posterior segment ophthalmic complications of aplastic anemia.', Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye, vol. 41 Online.
Agarwal, Monica ; Yeh, Steven ; Faia, Lisa J. ; Bishop, Rachel J. ; Lai, Michael M. ; Pantin, Jeremy Mark ; Scheinberg, Phillip ; Chew, Emily Y. ; Weichel, Eric D. / Posterior segment ophthalmic complications of aplastic anemia. In: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye. 2010 ; Vol. 41 Online.
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