Posttranslational modification and quality control

Xuejun Wang, J. Scott Pattison, Huabo Su

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Protein quality control functions to minimize the level and toxicity of misfolded proteins in the cell. Protein quality control is performed by intricate collaboration among chaperones and target protein degradation. The latter is performed primarily by the ubiquitin-proteasome system and perhaps autophagy. Terminally misfolded proteins that are not timely removed tend to form aggregates. Their clearance requires macroautophagy. Macroautophagy serves in intracellular quality control also by selectively segregating defective organelles (eg, mitochondria) and targeting them for degradation by the lysosome. Inadequate protein quality control is observed in a large subset of failing human hearts with a variety of causes, and its pathogenic role has been experimentally demonstrated. Multiple posttranslational modifications can occur to substrate proteins and protein quality control machineries, promoting or hindering the removal of the misfolded proteins. This article highlights recent advances in posttranslational modification-mediated regulation of intracellular quality control mechanisms and its known involvement in cardiac pathology.

Original languageEnglish (US)
Pages (from-to)367-381
Number of pages15
JournalCirculation research
Volume112
Issue number2
DOIs
StatePublished - Jan 18 2013
Externally publishedYes

Fingerprint

Post Translational Protein Processing
Quality Control
Autophagy
Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Lysosomes
Organelles
Proteolysis
Mitochondria
Pathology

Keywords

  • autophagy
  • chaperone-mediated autophagy
  • chaperones
  • deubiquitination
  • neddylation
  • phosphorylation
  • ubiquitin-proteasome system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Posttranslational modification and quality control. / Wang, Xuejun; Pattison, J. Scott; Su, Huabo.

In: Circulation research, Vol. 112, No. 2, 18.01.2013, p. 367-381.

Research output: Contribution to journalReview article

Wang, Xuejun ; Pattison, J. Scott ; Su, Huabo. / Posttranslational modification and quality control. In: Circulation research. 2013 ; Vol. 112, No. 2. pp. 367-381.
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