Post‐translational processing in model neuroendocrine systems: Precursors and products that coordinate reproductive activity in Aplysia and Lymnaea

Gregg Thomas Nagle, S. D. Painter, J. E. Blankenship

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The regulation of egg‐laying behavior in the hermaphroditic marine mollusc Aplysia has been an important model system that has provided insight into the cellular and molecular bases of neuroendocrine function. The advantages of this system derive primarily from the unique characteristics of the bag cells, two clusters of neurosecretory cells whose peptide products initiate and coordinate egg deposition. In particular, the large number of bag cell neurons in a single animal and their relative isolation from other elements of the nervous system facilitate biochemical analyses of the peptides synthesized and released by the cells. Moreover, the episodic nature of bag cell electrical activity, combined with the relative simplicity of the Aplysia nervous system and the stereotypic nature of the behaviors exhibited during egg deposition, provide unusually favorable opportunities for investigating neuropeptide action and function. This review will focus on neuropeptide synthesis and processing in the bag cells and in other organs expressing structurally related genes.

Original languageEnglish (US)
Pages (from-to)359-370
Number of pages12
JournalJournal of Neuroscience Research
Volume23
Issue number4
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Lymnaea
Aplysia
Neurosecretory Systems
Neuropeptides
Nervous System
Ovum
Peptides
Mollusca
Cell Count
Neurons
Genes

Keywords

  • bag cells
  • egg‐laying hormone
  • molluscan neuropeptides
  • peptide families

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Post‐translational processing in model neuroendocrine systems : Precursors and products that coordinate reproductive activity in Aplysia and Lymnaea. / Nagle, Gregg Thomas; Painter, S. D.; Blankenship, J. E.

In: Journal of Neuroscience Research, Vol. 23, No. 4, 01.01.1989, p. 359-370.

Research output: Contribution to journalReview article

@article{66cd83250f96492380f2f11f3af28f6d,
title = "Post‐translational processing in model neuroendocrine systems: Precursors and products that coordinate reproductive activity in Aplysia and Lymnaea",
abstract = "The regulation of egg‐laying behavior in the hermaphroditic marine mollusc Aplysia has been an important model system that has provided insight into the cellular and molecular bases of neuroendocrine function. The advantages of this system derive primarily from the unique characteristics of the bag cells, two clusters of neurosecretory cells whose peptide products initiate and coordinate egg deposition. In particular, the large number of bag cell neurons in a single animal and their relative isolation from other elements of the nervous system facilitate biochemical analyses of the peptides synthesized and released by the cells. Moreover, the episodic nature of bag cell electrical activity, combined with the relative simplicity of the Aplysia nervous system and the stereotypic nature of the behaviors exhibited during egg deposition, provide unusually favorable opportunities for investigating neuropeptide action and function. This review will focus on neuropeptide synthesis and processing in the bag cells and in other organs expressing structurally related genes.",
keywords = "bag cells, egg‐laying hormone, molluscan neuropeptides, peptide families",
author = "Nagle, {Gregg Thomas} and Painter, {S. D.} and Blankenship, {J. E.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1002/jnr.490230402",
language = "English (US)",
volume = "23",
pages = "359--370",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Post‐translational processing in model neuroendocrine systems

T2 - Precursors and products that coordinate reproductive activity in Aplysia and Lymnaea

AU - Nagle, Gregg Thomas

AU - Painter, S. D.

AU - Blankenship, J. E.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The regulation of egg‐laying behavior in the hermaphroditic marine mollusc Aplysia has been an important model system that has provided insight into the cellular and molecular bases of neuroendocrine function. The advantages of this system derive primarily from the unique characteristics of the bag cells, two clusters of neurosecretory cells whose peptide products initiate and coordinate egg deposition. In particular, the large number of bag cell neurons in a single animal and their relative isolation from other elements of the nervous system facilitate biochemical analyses of the peptides synthesized and released by the cells. Moreover, the episodic nature of bag cell electrical activity, combined with the relative simplicity of the Aplysia nervous system and the stereotypic nature of the behaviors exhibited during egg deposition, provide unusually favorable opportunities for investigating neuropeptide action and function. This review will focus on neuropeptide synthesis and processing in the bag cells and in other organs expressing structurally related genes.

AB - The regulation of egg‐laying behavior in the hermaphroditic marine mollusc Aplysia has been an important model system that has provided insight into the cellular and molecular bases of neuroendocrine function. The advantages of this system derive primarily from the unique characteristics of the bag cells, two clusters of neurosecretory cells whose peptide products initiate and coordinate egg deposition. In particular, the large number of bag cell neurons in a single animal and their relative isolation from other elements of the nervous system facilitate biochemical analyses of the peptides synthesized and released by the cells. Moreover, the episodic nature of bag cell electrical activity, combined with the relative simplicity of the Aplysia nervous system and the stereotypic nature of the behaviors exhibited during egg deposition, provide unusually favorable opportunities for investigating neuropeptide action and function. This review will focus on neuropeptide synthesis and processing in the bag cells and in other organs expressing structurally related genes.

KW - bag cells

KW - egg‐laying hormone

KW - molluscan neuropeptides

KW - peptide families

UR - http://www.scopus.com/inward/record.url?scp=0024431343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024431343&partnerID=8YFLogxK

U2 - 10.1002/jnr.490230402

DO - 10.1002/jnr.490230402

M3 - Review article

C2 - 2671398

AN - SCOPUS:0024431343

VL - 23

SP - 359

EP - 370

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 4

ER -