Potassium channels and the coronary circulation

Kevin C Dellsperger

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1. Mechanisms responsible for the regulation of coronary blood flow during physiologically important situations, such as reactive hyperaemia, hypoxia, ischaemia, coronary artery occlusion and increased metabolic demand, have eluded the scientific community, 2. As knowledge regarding potassium channel physiology and biophysics has expanded, the potential role of these channels in regulating coronary blood flow has been studied. 3. Recent data have demonstrated that ATP-sensitive potassium channels (K+([ATP])) an important in maintaining basal coronary blood flow, contribute to the regulation of coronary blood flow during hypoxia, acidosis, ischaemia, reactive hyperaemia and ischaemic preconditioning. The role of potassium channels in the regulation of coronary blood flow during increases in metabolic stimulation is controversial, 4. Thus, potassium channels, particularly K+([ATP]), appear to play an important role in regulating coronary blood flow during physiologically important stimuli.

Original languageEnglish (US)
Pages (from-to)1096-1101
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume23
Issue number12
DOIs
StatePublished - Jan 1 1996

Fingerprint

Coronary Circulation
Potassium Channels
Hyperemia
Ischemia
Adenosine Triphosphate
Biophysics
KATP Channels
Ischemic Preconditioning
Coronary Occlusion
Acidosis
Coronary Vessels

Keywords

  • ATP-sensitive potassium channels
  • Autoregulation
  • Coronary microcirculation
  • Reactive hyperaemia

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Potassium channels and the coronary circulation. / Dellsperger, Kevin C.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 23, No. 12, 01.01.1996, p. 1096-1101.

Research output: Contribution to journalArticle

Dellsperger, Kevin C. / Potassium channels and the coronary circulation. In: Clinical and Experimental Pharmacology and Physiology. 1996 ; Vol. 23, No. 12. pp. 1096-1101.
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