Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid

Subramaniam Pennathur, Dhiman Maitra, Jaeman Byun, Inga Sliskovic, Ibrahim Abdulhamid, Ghassan M. Saed, Michael Peter Diamond, Husam M. Abu-Soud

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Lycopene, a carotenoid found in tomatoes, is a proven antioxidant that may lower the risk of certain disorders including heart disease and cancer. Hypochlorous acid (HOCl) is an oxidant linked to tissue oxidation in cardiovascular disease and other inflammatory disorders through its ability to modify proteins, deoxyribonucleic acid, ribonucleic acid, and lipids. Here we show that lycopene can function as a potent scavenger of HOCl at a wide range of concentrations that span various pathophysiological and supplemental ranges. The oxidation of lycopene by HOCl was accompanied by a marked change in color, from red to colorless, of the lycopene solution, suggesting lycopene degradation. HPLC and LC-MS analysis showed that the exposure of lycopene to increasing concentrations of HOCl gave a range of metabolites resulting from oxidative cleavage of one or more C = C. The degree of degradation of lycopene (as assessed by the number and chain lengths of the various oxidative metabolites of lycopene) depends mainly on the ratio of HOCl to lycopene, suggesting that multiple molecules of HOCl are consumed per molecule of lycopene. Collectively, this work demonstrates a direct link between lycopene and HOCl scavenging and may assist in elucidating the mechanism of the protective function exerted by lycopene.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalFree Radical Biology and Medicine
Volume49
Issue number2
DOIs
StatePublished - Jul 1 2010

Fingerprint

Hypochlorous Acid
Scavenging
Metabolites
lycopene
Degradation
Oxidation
Heart Neoplasms
Molecules
Carotenoids
Lycopersicon esculentum
Chain length
Oxidants
Heart Diseases
Cardiovascular Diseases

Keywords

  • Carotenoid oxidation
  • Free radicals
  • Hypochlorous acid
  • Lycopene
  • Myeloperoxidase

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Pennathur, S., Maitra, D., Byun, J., Sliskovic, I., Abdulhamid, I., Saed, G. M., ... Abu-Soud, H. M. (2010). Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid. Free Radical Biology and Medicine, 49(2), 205-213. https://doi.org/10.1016/j.freeradbiomed.2010.04.003

Potent antioxidative activity of lycopene : A potential role in scavenging hypochlorous acid. / Pennathur, Subramaniam; Maitra, Dhiman; Byun, Jaeman; Sliskovic, Inga; Abdulhamid, Ibrahim; Saed, Ghassan M.; Diamond, Michael Peter; Abu-Soud, Husam M.

In: Free Radical Biology and Medicine, Vol. 49, No. 2, 01.07.2010, p. 205-213.

Research output: Contribution to journalArticle

Pennathur, S, Maitra, D, Byun, J, Sliskovic, I, Abdulhamid, I, Saed, GM, Diamond, MP & Abu-Soud, HM 2010, 'Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid', Free Radical Biology and Medicine, vol. 49, no. 2, pp. 205-213. https://doi.org/10.1016/j.freeradbiomed.2010.04.003
Pennathur, Subramaniam ; Maitra, Dhiman ; Byun, Jaeman ; Sliskovic, Inga ; Abdulhamid, Ibrahim ; Saed, Ghassan M. ; Diamond, Michael Peter ; Abu-Soud, Husam M. / Potent antioxidative activity of lycopene : A potential role in scavenging hypochlorous acid. In: Free Radical Biology and Medicine. 2010 ; Vol. 49, No. 2. pp. 205-213.
@article{0ce115abc0dd45d5bb80c0e21e1f4776,
title = "Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid",
abstract = "Lycopene, a carotenoid found in tomatoes, is a proven antioxidant that may lower the risk of certain disorders including heart disease and cancer. Hypochlorous acid (HOCl) is an oxidant linked to tissue oxidation in cardiovascular disease and other inflammatory disorders through its ability to modify proteins, deoxyribonucleic acid, ribonucleic acid, and lipids. Here we show that lycopene can function as a potent scavenger of HOCl at a wide range of concentrations that span various pathophysiological and supplemental ranges. The oxidation of lycopene by HOCl was accompanied by a marked change in color, from red to colorless, of the lycopene solution, suggesting lycopene degradation. HPLC and LC-MS analysis showed that the exposure of lycopene to increasing concentrations of HOCl gave a range of metabolites resulting from oxidative cleavage of one or more C = C. The degree of degradation of lycopene (as assessed by the number and chain lengths of the various oxidative metabolites of lycopene) depends mainly on the ratio of HOCl to lycopene, suggesting that multiple molecules of HOCl are consumed per molecule of lycopene. Collectively, this work demonstrates a direct link between lycopene and HOCl scavenging and may assist in elucidating the mechanism of the protective function exerted by lycopene.",
keywords = "Carotenoid oxidation, Free radicals, Hypochlorous acid, Lycopene, Myeloperoxidase",
author = "Subramaniam Pennathur and Dhiman Maitra and Jaeman Byun and Inga Sliskovic and Ibrahim Abdulhamid and Saed, {Ghassan M.} and Diamond, {Michael Peter} and Abu-Soud, {Husam M.}",
year = "2010",
month = "7",
day = "1",
doi = "10.1016/j.freeradbiomed.2010.04.003",
language = "English (US)",
volume = "49",
pages = "205--213",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Potent antioxidative activity of lycopene

T2 - A potential role in scavenging hypochlorous acid

AU - Pennathur, Subramaniam

AU - Maitra, Dhiman

AU - Byun, Jaeman

AU - Sliskovic, Inga

AU - Abdulhamid, Ibrahim

AU - Saed, Ghassan M.

AU - Diamond, Michael Peter

AU - Abu-Soud, Husam M.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Lycopene, a carotenoid found in tomatoes, is a proven antioxidant that may lower the risk of certain disorders including heart disease and cancer. Hypochlorous acid (HOCl) is an oxidant linked to tissue oxidation in cardiovascular disease and other inflammatory disorders through its ability to modify proteins, deoxyribonucleic acid, ribonucleic acid, and lipids. Here we show that lycopene can function as a potent scavenger of HOCl at a wide range of concentrations that span various pathophysiological and supplemental ranges. The oxidation of lycopene by HOCl was accompanied by a marked change in color, from red to colorless, of the lycopene solution, suggesting lycopene degradation. HPLC and LC-MS analysis showed that the exposure of lycopene to increasing concentrations of HOCl gave a range of metabolites resulting from oxidative cleavage of one or more C = C. The degree of degradation of lycopene (as assessed by the number and chain lengths of the various oxidative metabolites of lycopene) depends mainly on the ratio of HOCl to lycopene, suggesting that multiple molecules of HOCl are consumed per molecule of lycopene. Collectively, this work demonstrates a direct link between lycopene and HOCl scavenging and may assist in elucidating the mechanism of the protective function exerted by lycopene.

AB - Lycopene, a carotenoid found in tomatoes, is a proven antioxidant that may lower the risk of certain disorders including heart disease and cancer. Hypochlorous acid (HOCl) is an oxidant linked to tissue oxidation in cardiovascular disease and other inflammatory disorders through its ability to modify proteins, deoxyribonucleic acid, ribonucleic acid, and lipids. Here we show that lycopene can function as a potent scavenger of HOCl at a wide range of concentrations that span various pathophysiological and supplemental ranges. The oxidation of lycopene by HOCl was accompanied by a marked change in color, from red to colorless, of the lycopene solution, suggesting lycopene degradation. HPLC and LC-MS analysis showed that the exposure of lycopene to increasing concentrations of HOCl gave a range of metabolites resulting from oxidative cleavage of one or more C = C. The degree of degradation of lycopene (as assessed by the number and chain lengths of the various oxidative metabolites of lycopene) depends mainly on the ratio of HOCl to lycopene, suggesting that multiple molecules of HOCl are consumed per molecule of lycopene. Collectively, this work demonstrates a direct link between lycopene and HOCl scavenging and may assist in elucidating the mechanism of the protective function exerted by lycopene.

KW - Carotenoid oxidation

KW - Free radicals

KW - Hypochlorous acid

KW - Lycopene

KW - Myeloperoxidase

UR - http://www.scopus.com/inward/record.url?scp=77953543391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953543391&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2010.04.003

DO - 10.1016/j.freeradbiomed.2010.04.003

M3 - Article

C2 - 20388538

AN - SCOPUS:77953543391

VL - 49

SP - 205

EP - 213

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 2

ER -