Potential implication of N-acetylcysteine detoxification on adhesive endodontics.

Huang Xueqing, Zuo Chenqi, D. Xijin, Chen Huabing, Huang Cui, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

Abstract

Methacrylate resin-based dentin adhesives and root canal sealers used for bonding of filling materials inside the root canal system are cytotoxic and result in reduction in cell proliferation to a variable extent. An in vitro study to examine the detoxifying effects of N-acetylcysteine (NAC) on four commercial adhesive systems on adhesive-induced cytotoxicity and cell survival was conducted so that the use of methacrylate resin-based materials for filling root canals could be optimized. The finding that NAC co-treatment protected the cells from adhesive-induced toxicity by increasing cellular proliferation, attenuating cell cycle arrest, and reducing cell death suggests the null hypothesis that NAC has no effect on dentin adhesive-induced cell death and cell cycle arrest should be rejected.

Original languageEnglish (US)
JournalCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
Volume33
Issue number4
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Endodontics
Acetylcysteine
Adhesives
Root Canal Filling Materials
Methacrylates
Dentin
Cell Cycle Checkpoints
Cell Death
Cell Proliferation
Dental Pulp Cavity
Cell Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Potential implication of N-acetylcysteine detoxification on adhesive endodontics. / Xueqing, Huang; Chenqi, Zuo; Xijin, D.; Huabing, Chen; Cui, Huang; Tay, Franklin Chi Meng.

In: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), Vol. 33, No. 4, 01.01.2012.

Research output: Contribution to journalArticle

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