Potential of bone marrow stromal cells in applications for neuro-degenerative, neuro-traumatic and muscle degenerative diseases

Mari Dezawa, Hiroto Ishikawa, Mikio Hoshino, Yutaka Itokazu, Yo Ichi Nabeshima

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Cell transplantation is a promising strategy for the treatment of neurodegenerative and muscle degenerative diseases. Many kinds of cells, including embryonic stem cells and tissue stem cells, have been considered as candidates for transplantation therapy. Bone marrow stromal cells (MSCs) have great potential as therapeutic agents since they are easy to isolate and can be expanded from patients without serious ethical or technical problems. We discovered a new method for the highly efficient and specific induction of functional Schwann cells, neurons and skeletal muscle lineage cells from both rat and human MSCs. These induced cells were transplanted into animal models of neurotraumatic injuries, Parkinson's disease, stroke and muscle dystrophies, resulting in the successful integration of transplanted cells and an improvement in behavior of the transplanted animals. Here we focus on the respective potentials of MSC-derived cells and discuss the possibility of clinical application in degenerative diseases.

Original languageEnglish (US)
Pages (from-to)257-266
Number of pages10
JournalCurrent Neuropharmacology
Volume3
Issue number4
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

    Fingerprint

Keywords

  • Cell therapy
  • Mesenchymal cell
  • Myogenic differentiation
  • Neuronal differentiation
  • Regenerative medicine
  • Schwann cells
  • Transdifferentiation
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this