Abstract
In dexamethasone-treated PBMC isolated from control patients, or in cells obtained from immunosuppressed liver transplant patients, GM-CSF was found to selectively restore the innate immune response, without activating the specific immune response implicated in graft rejection. Moreover, GM-CSF efficiently restored the immune response against an otherwise lethal bacterial infection in immunosuppressed mice, without inducing the rejection of a skin transplant. These recent data could have implications for clinical practice and suggest a more detailed evaluation of agents with similar actions to GM-CSF in the restoration of innate immunity in organ transplant patients.
Original language | English (US) |
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Pages (from-to) | 411-417 |
Number of pages | 7 |
Journal | Current Opinion in Organ Transplantation |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2004 |
Externally published | Yes |
Keywords
- G-CSF
- GM-CSF
- Immunity
- Infection
- Transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation