Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

David H. Munn, Madhav D. Sharma, Jeffrey R. Lee, Kanchan G. Jhaver, Theodore S. Johnson, Derin B. Keskin, Brendan Marshall, Phillip Chandler, Scott J. Antonia, Russell Burgess, Craig L. Slingluff, Andrew L. Mellor

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795 Scopus citations

Abstract

Antigen-presenting cells (APCS) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

Original languageEnglish (US)
Pages (from-to)1867-1870
Number of pages4
JournalScience
Volume297
Issue number5588
DOIs
StatePublished - Sep 13 2002

ASJC Scopus subject areas

  • General

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    Munn, D. H., Sharma, M. D., Lee, J. R., Jhaver, K. G., Johnson, T. S., Keskin, D. B., Marshall, B., Chandler, P., Antonia, S. J., Burgess, R., Slingluff, C. L., & Mellor, A. L. (2002). Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science, 297(5588), 1867-1870. https://doi.org/10.1126/science.1073514