Abstract
Antigen-presenting cells (APCS) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
Original language | English (US) |
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Pages (from-to) | 1867-1870 |
Number of pages | 4 |
Journal | Science |
Volume | 297 |
Issue number | 5588 |
DOIs | |
State | Published - Sep 13 2002 |
ASJC Scopus subject areas
- General