Potential role of endothelin receptor antagonists in the setting of cardiopulmonary bypass: Relevance to myocardial performance

Adviye Ergul, Cassandra Joffs, Allyson C. Walker, Francis G. Spinale

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The ET ssytem is activated in cardiac surgical setting as evidenced by elevated systemic and myocardial ET-1 levels after coronary bypass grafting surgery which requires hypothermic cardioplegic arrest and cardiopulmonary bypass. Increased ET-1 may influence a number of clinical parameters in this setting. First, ET-1 may directly modulate myocardial contractile performance in the early postoperative period resulting in LV dysfunction and a complex postoperative course. Second, elevated ET-1 levels may exacerbate increased pulmonary vascular resistance and contribute to the development of transient pulmonary hypertension following bypass. Finally, augmented postoperative ET-1 levels could contribute to changes in the caliber and flow of vascular conduits used for coronary bypass. In this review, a current perspective on the ET system in the setting of cardiopulmonary bypass grafting surgery is provided and the potential use of ET receptor antagonists in this setting is discussed.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalHeart Failure Reviews
Volume6
Issue number4
DOIs
StatePublished - Aug 20 2001

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Keywords

  • Cardioplegic arrest
  • Cardiopulmonary bypass grafting
  • Endothelin
  • Receptor antagonist

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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