Potentiation of Purified Erythropoietin with Serum Proteins. II

Serial Dose Response Relationships

Russell R Moores, Edward Gardner, Claude Starr Wright, Jasper P. Lewis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Erythropoietin (urinary fraction II + III) was diluted with either saline or normal serum and injected into assay animals as a single dose or as 2 or 4 fractional doses either intraperitoneally or subcutaneously. Erythropoietic activity increased as the dose was fractionated; however, the erythropoietin plus serum showed greater activity than erythropoietin plus saline in all dosage schedules. This suggests that normal serum actually enhances the activity of erythropoietin rather than merely acting as an adjuvant causing delayed absorption of the material. Grateful acknowledgement is made to Miss Bettie Williams and Mrs. Carol Cope for fine technical assistance, to Dr. Charles B. Bragassa, Mrs. Rebecca Bedingfield and Mr. Bob Ellis of the Computer Center, Medical College of Georgia, for statistical analyses and to Mrs. Margaret Hiers and Mrs. Shirl Melton for secretarial assistance.

Original languageEnglish (US)
Pages (from-to)618-620
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume123
Issue number2
DOIs
StatePublished - Jan 1 1966

Fingerprint

Erythropoietin
Blood Proteins
Serum
Assays
Appointments and Schedules
Animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Potentiation of Purified Erythropoietin with Serum Proteins. II : Serial Dose Response Relationships. / Moores, Russell R; Gardner, Edward; Wright, Claude Starr; Lewis, Jasper P.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 123, No. 2, 01.01.1966, p. 618-620.

Research output: Contribution to journalArticle

Moores, Russell R ; Gardner, Edward ; Wright, Claude Starr ; Lewis, Jasper P. / Potentiation of Purified Erythropoietin with Serum Proteins. II : Serial Dose Response Relationships. In: Proceedings of the Society for Experimental Biology and Medicine. 1966 ; Vol. 123, No. 2. pp. 618-620.
@article{ca0ecb4ed9d0424c89e57baf59c89e91,
title = "Potentiation of Purified Erythropoietin with Serum Proteins. II: Serial Dose Response Relationships",
abstract = "Erythropoietin (urinary fraction II + III) was diluted with either saline or normal serum and injected into assay animals as a single dose or as 2 or 4 fractional doses either intraperitoneally or subcutaneously. Erythropoietic activity increased as the dose was fractionated; however, the erythropoietin plus serum showed greater activity than erythropoietin plus saline in all dosage schedules. This suggests that normal serum actually enhances the activity of erythropoietin rather than merely acting as an adjuvant causing delayed absorption of the material. Grateful acknowledgement is made to Miss Bettie Williams and Mrs. Carol Cope for fine technical assistance, to Dr. Charles B. Bragassa, Mrs. Rebecca Bedingfield and Mr. Bob Ellis of the Computer Center, Medical College of Georgia, for statistical analyses and to Mrs. Margaret Hiers and Mrs. Shirl Melton for secretarial assistance.",
author = "Moores, {Russell R} and Edward Gardner and Wright, {Claude Starr} and Lewis, {Jasper P.}",
year = "1966",
month = "1",
day = "1",
doi = "10.3181/00379727-123-31560",
language = "English (US)",
volume = "123",
pages = "618--620",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "Society for Experimental Biology and Medicine",
number = "2",

}

TY - JOUR

T1 - Potentiation of Purified Erythropoietin with Serum Proteins. II

T2 - Serial Dose Response Relationships

AU - Moores, Russell R

AU - Gardner, Edward

AU - Wright, Claude Starr

AU - Lewis, Jasper P.

PY - 1966/1/1

Y1 - 1966/1/1

N2 - Erythropoietin (urinary fraction II + III) was diluted with either saline or normal serum and injected into assay animals as a single dose or as 2 or 4 fractional doses either intraperitoneally or subcutaneously. Erythropoietic activity increased as the dose was fractionated; however, the erythropoietin plus serum showed greater activity than erythropoietin plus saline in all dosage schedules. This suggests that normal serum actually enhances the activity of erythropoietin rather than merely acting as an adjuvant causing delayed absorption of the material. Grateful acknowledgement is made to Miss Bettie Williams and Mrs. Carol Cope for fine technical assistance, to Dr. Charles B. Bragassa, Mrs. Rebecca Bedingfield and Mr. Bob Ellis of the Computer Center, Medical College of Georgia, for statistical analyses and to Mrs. Margaret Hiers and Mrs. Shirl Melton for secretarial assistance.

AB - Erythropoietin (urinary fraction II + III) was diluted with either saline or normal serum and injected into assay animals as a single dose or as 2 or 4 fractional doses either intraperitoneally or subcutaneously. Erythropoietic activity increased as the dose was fractionated; however, the erythropoietin plus serum showed greater activity than erythropoietin plus saline in all dosage schedules. This suggests that normal serum actually enhances the activity of erythropoietin rather than merely acting as an adjuvant causing delayed absorption of the material. Grateful acknowledgement is made to Miss Bettie Williams and Mrs. Carol Cope for fine technical assistance, to Dr. Charles B. Bragassa, Mrs. Rebecca Bedingfield and Mr. Bob Ellis of the Computer Center, Medical College of Georgia, for statistical analyses and to Mrs. Margaret Hiers and Mrs. Shirl Melton for secretarial assistance.

UR - http://www.scopus.com/inward/record.url?scp=0013973385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013973385&partnerID=8YFLogxK

U2 - 10.3181/00379727-123-31560

DO - 10.3181/00379727-123-31560

M3 - Article

VL - 123

SP - 618

EP - 620

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 2

ER -